Dopaminergic Enhancement of Learning and Memory in Aphasia
NCT ID: NCT00102869
Last Updated: 2013-10-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
12 participants
INTERVENTIONAL
2005-01-31
2008-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Interventions
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levodopa
100mg levodopa per day over 10 days/ treatment phase
Eligibility Criteria
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Inclusion Criteria
* Time post onset: \> 6 months
* Aphasia with anomia
* Age between 18-75 years
* Premorbid right-handedness
* Primary language: German
Exclusion Criteria
* History of medication/drug abuse
* Acute nicotine withdrawal or \> 15 cigarettes per day
* \> 6 cups/glasses of coffee, caffeine drinks or energy drinks per day
* \> 50 grams of alcohol per day
* Severe hypertonia (systole \>180 mm Hg)
* Severe arteriosclerosis
* Diabetes, asthma, or glaucoma
* Severe hearing disability
* Evidence for severe hippocampal damage
* Premorbid depression or psychosis
* Medication with dopamine agonists or antagonists
* Parkinsonian symptoms
* Changes in anticonvulsive medication during the week prior to study enrollment
18 Years
75 Years
ALL
Yes
Sponsors
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German Federal Ministry of Education and Research
OTHER_GOV
University Hospital Muenster
OTHER
Responsible Party
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Bundesministerium für Bildung und Forschung (BMBF)
Principal Investigators
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Caterina Breitenstein, PhD
Role: STUDY_DIRECTOR
Dept. of Neurology, University Hospital Muenster, Germany
Stefan Knecht, MD
Role: STUDY_CHAIR
Dept. of Neurology, University Hospital Muenster, Germany
Locations
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Dept. of Neurology, University Hospital Muenster
Münster, North Rhine-Westphalia, Germany
Countries
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References
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Knecht S, Breitenstein C, Bushuven S, Wailke S, Kamping S, Floel A, Zwitserlood P, Ringelstein EB. Levodopa: faster and better word learning in normal humans. Ann Neurol. 2004 Jul;56(1):20-6. doi: 10.1002/ana.20125.
Breitenstein C, Wailke S, Bushuven S, Kamping S, Zwitserlood P, Ringelstein EB, Knecht S. D-amphetamine boosts language learning independent of its cardiovascular and motor arousing effects. Neuropsychopharmacology. 2004 Sep;29(9):1704-14. doi: 10.1038/sj.npp.1300464.
Breitenstein C, Knecht S. [Language acquisition and statistical learning]. Nervenarzt. 2003 Feb;74(2):133-43. doi: 10.1007/s00115-002-1466-1. German.
Breitenstein C, Korsukewitz C, Baumgartner A, Floel A, Zwitserlood P, Dobel C, Knecht S. L-dopa does not add to the success of high-intensity language training in aphasia. Restor Neurol Neurosci. 2015;33(2):115-20. doi: 10.3233/RNN-140435.
Other Identifiers
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LL_001, Project on aphasia
Identifier Type: -
Identifier Source: org_study_id
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