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Lung Cancer Screening Eligibility Assessment

NCT ID: NCT06133816

Last Updated: 2025-05-31

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-31

Study Completion Date

2024-01-31

Brief Summary

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The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

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Detailed Description

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Despite growing evidence that lung cancer screening (LCS) reduces lung cancer-specific mortality, LCS across the United States is remarkably low. This is due in part to challenges with identifying adults who meet eligibility criteria for lifetime smoking intensity (i.e., 20 pack-years or greater), which is often missing from the electronic medical record. We have developed a simplified eligibility tool that has shown accuracy in estimating pack-years. But given the potential for low response rates, there is a great need to identify effective strategies to increasing response rates equitably prior to using it in practice or in future studies. The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help to identify the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Conditions

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Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

We will use a randomized factorial design to test the effects of different types of messaging with or without incentives on response rates to an eligibility survey.
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)

Participants will receive two framed messages (AA) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 2 (Introductory Message A + Tobacco Use Message A)

Participants will receive two framed messages (AA)

Group Type EXPERIMENTAL

Framed Introductory Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)

Participants will receive two framed messages (AB) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 4 (Introductory Message A + Tobacco Use Message B)

Participants will receive two framed messages (AB)

Group Type EXPERIMENTAL

Framed Introductory Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)

Participants will receive two framed messages (BA) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 6 (Introductory Message B + Tobacco Use Message A)

Participants will receive two framed messages (BA)

Group Type EXPERIMENTAL

Framed Introductory Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)

Participants will receive two framed messages (BB) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 8 (Introductory Message B + Tobacco Use Message B)

Participants will receive two framed messages (BB)

Group Type EXPERIMENTAL

Framed Introductory Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

Participants will receive two framed messages (CA) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message C

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 10 (Introductory Message C + Tobacco Use Message A)

Participants will receive two framed message (CA)

Group Type EXPERIMENTAL

Framed Introductory Message C

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Framed Tobacco Use Message A

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)

Participants will receive two framed messages (CB) plus an incentive

Group Type EXPERIMENTAL

Financial Incentive

Intervention Type BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Framed Introductory Message C

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 12 (Introductory Message C + Tobacco Use Message B)

Participants will receive two framed messages (CB)

Group Type EXPERIMENTAL

Framed Introductory Message C

Intervention Type BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Framed Tobacco Use Message B

Intervention Type BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Interventions

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Financial Incentive

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Intervention Type BEHAVIORAL

Framed Introductory Message A

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Intervention Type BEHAVIORAL

Framed Introductory Message B

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Intervention Type BEHAVIORAL

Framed Introductory Message C

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Intervention Type BEHAVIORAL

Framed Tobacco Use Message A

Randomly assign patients to receive norming message related to tobacco use (version A).

Intervention Type BEHAVIORAL

Framed Tobacco Use Message B

Randomly assign patients to receive norming message related to tobacco use (version B).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
2. have completed at least one primary care visit at Penn Medicine in 2020-2025

Exclusion Criteria

1. have a documented history of lung cancer;
2. have a documented history of completing LCS at Penn Medicine;
3. are listed as not wanting to be contacted or solicited for research; or
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Abramson Cancer Center at Penn Medicine

OTHER

Sponsor Role lead

Responsible Party

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Katharine Rendle

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Katharine A Rendle, PhD,MSW,MPH

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

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University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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P50CA271338-02

Identifier Type: NIH

Identifier Source: secondary_id

View Link

853337

Identifier Type: OTHER

Identifier Source: secondary_id

UPCC 16523

Identifier Type: -

Identifier Source: org_study_id

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