Detection of Aluminium-reactive T-lymphocytes in Patients With Vaccination Granulomas
NCT ID: NCT06130462
Last Updated: 2023-11-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
16 participants
INTERVENTIONAL
2022-09-13
2023-02-20
Brief Summary
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We include participants both with and without granulomas, all have a blood test taken where we investigate if any participants have aluminium-specific cirkulation cells, and whether we can detect a difference between participants with and without granulomas.
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Detailed Description
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An alternative to patch testing is the blood in vitro lymphocyte proliferation test (LPT), which we investigated using a well-established LPT protocol. This has previously been shown to detect and characterize metal-specific cells and was used to detect circulating aluminium-specific proliferation. The LPT test is based on a single blood sample and has mostly been used to detect drug hypersensitivity. Still, its role in detecting metal allergy is expanding, with recent studies suggesting using the test as a supplement to the patch test when only a few allergens are to be investigated.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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LPT aluminium
Investigation of participants with aluminium allergy versus healthy controls. Aluminium in different concentrations are added to the blood samples to elicit a response
Aluminum
Different concentrations of aluminium added to the blood test in vitro
LPT control
Tetanus toxoid was added to blood samples as control substance.
Tetanus toxoid
Used as control substance
Interventions
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Aluminum
Different concentrations of aluminium added to the blood test in vitro
Tetanus toxoid
Used as control substance
Eligibility Criteria
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Inclusion Criteria
* controls without granulomas and no suspected contact allergies
Exclusion Criteria
18 Years
65 Years
ALL
Yes
Sponsors
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National Allergy Research Center, Denmark
OTHER
Responsible Party
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Principal Investigators
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Lars Blom, PhD
Role: STUDY_DIRECTOR
Allergy clinic, Gentofte Hospital
Locations
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National Allergy Research Centre, Gentofte Hospital
Hellerup, , Denmark
Countries
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Other Identifiers
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H-20073116
Identifier Type: -
Identifier Source: org_study_id
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