Identification of Anaphylactogenic Antibodies in Peanut Allergy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-30

Study Completion Date

2025-12-31

Brief Summary

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This project intends the analysis and profiling of specific antibodies against major peanut allergens in peanut allergic individuals and molecular cloning of human antibodies against major peanut allergens.

Detailed Description

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* Characterization of patient samples reactivity (sera obtained from blood) against major peanut allergens.
* Isolation of antibody-producing B cells.
* Molecular cloning of peanut-specific antibodies from antibody gene sequences obtained from B cells.
* Biophysical and functional characterization of isolated antibodies

Conditions

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Peanut Allergy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Observational study

Blood sampling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Participants have a described clinical history of peanut allergy and/or are sensitized to peanut allergens (as evidenced by positive skin prick test and allergen-specific IgE testing)
* Male and female subjects older than 3 years
* Written informed consent

Exclusion Criteria

* age below three years
* patients suffering from any disease where blood withdrawals might impact the patients' health status such as known anemia.

Minimum Eligible Age

3 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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UZH

Identifier Type: -

Identifier Source: org_study_id