Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

NCT ID: NCT00789217

Last Updated: 2010-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-12-31

Study Completion Date

2010-08-31

Brief Summary

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This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.

Detailed Description

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The results of skin test with immediate reading will be compared between alkali-treated penicillin G and DAP reagents from Diater

Conditions

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Penicillin Allergy

Keywords

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Penicillin Beta-Lactams Allergy Hypersensitivity

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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In-house penicillin testing preparation

In-house penicillin testing prepared from alkali-treated penicillin G

Group Type ACTIVE_COMPARATOR

Immediate skin test

Intervention Type PROCEDURE

Intradermal test with immediate reading

Commercial penicillin test kit

Commercial penicillin test kit order from Diater company

Group Type ACTIVE_COMPARATOR

Immediate skin test

Intervention Type PROCEDURE

Intradermal test with immediate reading

Penicillin G Sodium

Penicillin G Sodium from routine clinical use

Group Type ACTIVE_COMPARATOR

Immediate skin test

Intervention Type PROCEDURE

Intradermal test with immediate reading

Interventions

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Immediate skin test

Intradermal test with immediate reading

Intervention Type PROCEDURE

Other Intervention Names

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Intradermal test with reading at 15 minutes after injection

Eligibility Criteria

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Inclusion Criteria

1. Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins
2. 15-65 years of age

Exclusion Criteria

1. On antihistamine/ cannot discontinue antihistamine before the test
2. Having asthma exacerbation
3. Being pregnant
4. Suffering from severe systemic disease/ in bad health
Minimum Eligible Age

15 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mahidol University

OTHER

Sponsor Role collaborator

Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Chulalongkorn University

Principal Investigators

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Jettanong Klaewsongkram, MD

Role: PRINCIPAL_INVESTIGATOR

Chulalongkorn University

Locations

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Faculty of Medicine, Chulalongkorn University

Bangkok, , Thailand

Site Status

Countries

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Thailand

References

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Wangrattanasopon P, Ruxrungtham K, Chantaphakul H, Buranapraditkun S, Klaewsongkram J. Alkali-treated penicillin G solution is a better option than penicillin G as an alternative source of minor determinants for penicillin skin test. Allergy Asthma Proc. 2012 Mar-Apr;33(2):152-9. doi: 10.2500/aap.2012.33.3496.

Reference Type DERIVED
PMID: 22525392 (View on PubMed)

Other Identifiers

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Chula-ARC 001/08

Identifier Type: -

Identifier Source: org_study_id