tACS for Sensory Motor Recovery After Stroke

NCT ID: NCT06029062

Last Updated: 2025-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-01

Study Completion Date

2028-03-31

Brief Summary

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The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.

Detailed Description

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Conditions

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Motor Recovery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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tACS Sham, tACS 10Hz, tACS 20Hz

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.

tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Group Type EXPERIMENTAL

tACS Sham

Intervention Type DEVICE

Sham tACS will applied to the brain through the scalp for 20 minutes.

tACS 10Hz

Intervention Type DEVICE

10Hz tACS will applied to the brain through the scalp for 20 minutes.

tACS 20Hz

Intervention Type DEVICE

20Hz tACS will applied to the brain through the scalp for 20 minutes.

HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.

tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Group Type EXPERIMENTAL

tACS Sham

Intervention Type DEVICE

Sham tACS will applied to the brain through the scalp for 20 minutes.

tACS 10Hz

Intervention Type DEVICE

10Hz tACS will applied to the brain through the scalp for 20 minutes.

tACS 20Hz

Intervention Type DEVICE

20Hz tACS will applied to the brain through the scalp for 20 minutes.

HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.

tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.

tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Group Type EXPERIMENTAL

tACS Sham

Intervention Type DEVICE

Sham tACS will applied to the brain through the scalp for 20 minutes.

tACS 10Hz

Intervention Type DEVICE

10Hz tACS will applied to the brain through the scalp for 20 minutes.

tACS 20Hz

Intervention Type DEVICE

20Hz tACS will applied to the brain through the scalp for 20 minutes.

Interventions

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tACS Sham

Sham tACS will applied to the brain through the scalp for 20 minutes.

Intervention Type DEVICE

tACS 10Hz

10Hz tACS will applied to the brain through the scalp for 20 minutes.

Intervention Type DEVICE

tACS 20Hz

20Hz tACS will applied to the brain through the scalp for 20 minutes.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age between 18\~75 years old
2. ≥ 6 months post stroke, medically stable;
3. Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);
4. Visible finger flexor activation/movement
5. The ability to give consent

Exclusion Criteria

1. Patients with visual deficit/neglect; hearing or cognitive impairment;
2. Patients that are currently adjusting tone alternating medications (e.g., baclofen), or
3. Patients received botulinum toxin injection to the arm/fingers \<4 months, or phenol injections \<2 years;
4. Patients with pacemaker, metal implants or supplemental oxygen;
5. Patients who have musculoskeletal disorders, including pain in the affected side
6. Women who are pregnant.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Texas Health Science Center, Houston

OTHER

Sponsor Role lead

Responsible Party

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Sheng Li

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sheng Li, MD, Ph.D

Role: PRINCIPAL_INVESTIGATOR

The University of Texas Health Science Center, Houston

Locations

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The University of Texas Health Science Center

Houston, Texas, United States

Site Status

Countries

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United States

Central Contacts

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Sheng Li, MD, Ph.D

Role: CONTACT

(713) 797-7125

Shengai Li, MS

Role: CONTACT

713-797-7561

Facility Contacts

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Sheng Li, MD, PhD

Role: primary

713-797-7125

Shengai Li, MS

Role: backup

713-797-7561

Other Identifiers

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HSC-MS-22-0046 (Experiment 1)

Identifier Type: -

Identifier Source: org_study_id

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