CXCL2/CXCL8 Promote Intervertebral Disc Degeneration

NCT ID: NCT05976516

Last Updated: 2023-08-04

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-08-01
• Study Completion Date: 2024-03-30

Brief Summary

Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.

Conditions

Cytokine; Intervertebral Disc, Degenerative

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

pirffmann 2 grade

CXCL2/CXCL8

Intervention Type: DIAGNOSTIC_TEST

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

pirffmann 3 grade

CXCL2/CXCL8

Intervention Type: DIAGNOSTIC_TEST

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

pirffmann 4 grade

CXCL2/CXCL8

Intervention Type: DIAGNOSTIC_TEST

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

pirffmann 5 grade

CXCL2/CXCL8

Intervention Type: DIAGNOSTIC_TEST

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

Interventions

CXCL2/CXCL8

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• It meets the diagnostic criteria of lumbar disc degeneration; No previous history of spinal surgery; Good ability of independent behavior and cooperation in completing research; The patient is aware of this study and has signed the consent form.

Exclusion Criteria

• Patients with spinal tumor, infection, tuberculosis and other diseases; Patients with claustrophobia; Parkinson's syndrome patients; Poor cooperation, Poor image quality; Patients with osteoporosis.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zhongda Hospital

OTHER

Sponsor Role: lead

Responsible Party

pengfei, xue

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Zhongda Hospital

Nanjing, Jiangsu, China

Site Status: RECRUITING

Countries

China

Facility Contacts

Lei liu, Dr

Role: primary

18934544893@163.com

18934544893

Other Identifiers

20220224016

Identifier Type: -

Identifier Source: org_study_id