Influence of Autonomy on Motor Learning in People With Parkinson's Disease

NCT ID: NCT05960331

Last Updated: 2025-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-21

Study Completion Date

2025-12-31

Brief Summary

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The goal of this clinical trial is to explore the benefits of autonomy supported learning in patients with Parkinson's disease. The main questions to answer are:

* Whether autonomy supported learning can benefit motor learning in PD patients
* Whether autonomy supported learning can enhance intrinsic motivation and/ or information processing of PD patients in learning a new task.
* Whether autonomy supported learning can facilitate cortical excitability change after practicing a new task.

Participants will be recruited into two groups (Self-control group, SC; and yoked group, YK) to learn a finger-pressing trajectory matching task

* Participants in SC group will have choice over feedback schedule during trial practice
* Participants in YK group will receive feedback with no-choice during trial practice Researchers will compare the retention test performance to see if autonomy supported learning will lead to better learning effect.

Detailed Description

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Autonomy is the sense of learner to actively participate in determining their own behaviour. The present study aims to investigate whether an autonomy supported practice (with self-controlled feedback) would benefit adults with Parkinson's disease (PD), along with increased intrinsic motivation, information processing and cortical excitability. Two groups of healthy adults and two groups of PD patients will be recruited to learn a finger-pressing trajectory matching task. Participants will be allocated in either a self-control group (choice over feedback schedule), or a yoked group (receive feedback with no-choice). Learning will be assessed on the second day and one week later, along with an error estimation of learners' own performance to represent their information processing ability. Cortical excitability and inhibition will be assessed via transcranial magnetic stimulation as indicators of cortical plasticity. Questionnaire regarding motivation will be assessed before and after practice trials. Study hypothesized that individual with PD would benefit from autonomy supported learning, with better performance, enhanced motivation and information processing, associates with change of cortical excitability

Conditions

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Parkinson Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Self-control group

Participants will be able to choose over feedback schedule when practicing finger-pressing trajectory matching task.

Group Type EXPERIMENTAL

Autonomy supported learning

Intervention Type BEHAVIORAL

The ability of learners to participate in determining their own behaviour, which is the feedback schedule regarding their practice performance in this study.

Yoked group

Participants will receive feedback, which was determined by their counterpart in self-control group, with no-choice when practicing finger-pressing trajectory matching task.

Group Type ACTIVE_COMPARATOR

Practice with predetermined feedback

Intervention Type BEHAVIORAL

Learners practice the motor task, while the feedback is provided according to their counterpartner

Interventions

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Autonomy supported learning

The ability of learners to participate in determining their own behaviour, which is the feedback schedule regarding their practice performance in this study.

Intervention Type BEHAVIORAL

Practice with predetermined feedback

Learners practice the motor task, while the feedback is provided according to their counterpartner

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* age above 20-years-old
* able to follow instructions to perform the tasks (Montreal Cognitive Assessment ≥ 24)
* no surgery and injury in upper extremities in recent 6 months

Exclusion Criteria

* other neurological disorders in addition to Parkinson's disease
* Parkinson's disease dementia
* symptom of severe tremor in upper extremities (score ≥ 3 in Question 15 to 18 of UPDRS-III)
* deep brain stimulation or pacemaker implanted
* medical history of seizure
* a blood-relative with history of epilepsy
* unstable medical conditions
* pregnancy
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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YA-YUN LEE, PhD

Role: CONTACT

+886-2-33668155

DE-JUN LIM, Bachelor

Role: CONTACT

+886-9-66716146

Facility Contacts

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Ya-Yun Lee, PhD

Role: primary

+886-2-33668155

References

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Carter MJ, Ste-Marie DM. Not all choices are created equal: Task-relevant choices enhance motor learning compared to task-irrelevant choices. Psychon Bull Rev. 2017 Dec;24(6):1879-1888. doi: 10.3758/s13423-017-1250-7.

Reference Type RESULT
PMID: 28224481 (View on PubMed)

Chiviacowsky S, Wulf G, Lewthwaite R, Campos T. Motor learning benefits of self-controlled practice in persons with Parkinson's disease. Gait Posture. 2012 Apr;35(4):601-5. doi: 10.1016/j.gaitpost.2011.12.003. Epub 2011 Dec 30.

Reference Type RESULT
PMID: 22209649 (View on PubMed)

Other Identifiers

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202304047RINC

Identifier Type: -

Identifier Source: org_study_id

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