The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD

NCT ID: NCT06607653

Last Updated: 2024-09-23

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-09-25
• Study Completion Date: 2025-04-10

Brief Summary

To explore the efficacy of olfactory training on olfactory and other non-motor symptoms in PD.

Conditions

Parkinson Disease; Olfactory Disorder; Olfactory Training

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

OT grroup

Olfactory training used repeated stimulation of different olfactory substances at high concentrations, combined with odor association and odor identification training, twice in the morning and evening, each time for 5 minutes, for 15 weeks.

Group Type: EXPERIMENTAL

Olfactory training

Intervention Type: DEVICE

Olfactory training used repeated stimulation of different olfactory substances at high concentrations, combined with odor association and odor identification training, twice in the morning and evening, each time for 5 minutes, for 15 weeks.

No intervention group

There were only pre-test and post-test without any intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Olfactory training

Olfactory training used repeated stimulation of different olfactory substances at high concentrations, combined with odor association and odor identification training, twice in the morning and evening, each time for 5 minutes, for 15 weeks.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. PD was diagnosed according to the criteria of Movement Disorders and Parkinson Disease Group of Chinese Society of Neurology of Chinese Medical Association.

2. Olfactory score was 1 standard deviation lower than the corresponding age norm;

3. no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability;

5.Good cooperation of patients

Exclusion Criteria

1. Parkinson's syndrome and Parkinson's plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.;

2. Neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.;

3. History of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. Upper respiratory tract infection in the past 3 weeks;

4. Long-term smoking and occupations that inhale chemical irritants for a long time.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Anhui Medical University

OTHER

Sponsor Role: lead

Responsible Party

WANG KAI

Head, Dept of Neurology & Medical Psychology, Director, Cognitive Neuropsychology Lab, PRC

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cognitive Neuropsychology Lab Anhui Medical University

Hefei, Anhui, China

Countries

China

Facility Contacts

Panpan Hu

Role: primary

hpppanda9@126.com

13515602285

Other Identifiers

AHMU-PD-OT

Identifier Type: -

Identifier Source: org_study_id