The Profile of the Depression and it's Intervention Strategy in Patients With Parkinson's Disease in China
NCT ID: NCT03026595
Last Updated: 2018-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
500 participants
OBSERVATIONAL
2017-01-31
2018-12-31
Brief Summary
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Detailed Description
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Investigators' previous study on non-motor symptoms in 81 Chinese PD patients demonstrated that prevalence of loss of interest and depression(sadness) were 48.7% and 36.7% by Non-motor symptoms questionnaire (NMSQuest) separately, which was similar to average global data. But another Chinese data published in 2008 showed that the prevalence of depression in PD patients was only 12%, no statistical difference with controls(2%). Thus, investigators plan to initiate a larger study to understand if PD depression in China is similar to it in western countries.
Depression would occur at the early stage of the disease or proceed the motor symptoms, usually accompanied with other non-motor symptoms including apathy, sleep disorder, cognitive impairment, and etc. The effects of depression on quality of life might refer to a wider range. There is lack of solid data to reveal the harm of depression on quality of life of PD patients and caregivers. In clinical practice, the disease burden of PD depression is usually underestimated by physicians and patients.
Although PD depression affects QoL of patients and caregivers, PD depression would be relieved by medication, which was clearly recommended by international and Chinese PD guidelines. But the PD depression treatment status in Chinese clinical practice is not systematically analyzed before. In this study, investigator will summarize the treatment profile of PD depression to see if PD depression is properly treated according to guideline.
Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Interventions
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no intervention
no intervention
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Participate in a concurrent clinical trial.
18 Years
ALL
No
Sponsors
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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
OTHER
Responsible Party
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Principal Investigators
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Zhenguo Liu
Role: PRINCIPAL_INVESTIGATOR
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Locations
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Department of Neurology,Nanjing Brain Hospital,Nanjing Medical University
Nanjing, , China
Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Shanghai, , China
Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine
Shanghai, , China
Zhongshan Hospital & Shanghai Medical College, Fudan University
Shanghai, , China
Countries
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Central Contacts
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Facility Contacts
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Weiguo Liu
Role: primary
Canxin Yuan
Role: primary
Linjing Jin
Role: primary
Lirong Jin
Role: primary
References
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Gan J, Zhou M, Chen W, Liu Z. Non-motor symptoms in Chinese Parkinson's disease patients. J Clin Neurosci. 2014 May;21(5):751-4. doi: 10.1016/j.jocn.2013.07.015. Epub 2013 Sep 11.
Other Identifiers
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XH-16-047
Identifier Type: -
Identifier Source: org_study_id
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