Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

NCT ID: NCT05945771

Last Updated: 2023-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2022-08-31

Brief Summary

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The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Detailed Description

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Conditions

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Dietary Supplementation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Randomized double blind grape seed extract design

Grape seed extract

Group Type ACTIVE_COMPARATOR

Grape seed extract

Intervention Type DIETARY_SUPPLEMENT

Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

Control

Placebo (starch)

Group Type PLACEBO_COMPARATOR

Grape seed extract

Intervention Type DIETARY_SUPPLEMENT

Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

Interventions

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Grape seed extract

Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers (SBP \< 120 mmHg, DBP \< 80 mmHg)

Exclusion Criteria

* cardiovascular and/or pulmonary disease,
* musculoskeletal disorders
* medications that prevent the safe completion of the exercise protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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California Baptist University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jong-Kyung Kim

Role: PRINCIPAL_INVESTIGATOR

California Baptist University

Locations

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California Baptist University

Riverside, California, United States

Site Status

Countries

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United States

Other Identifiers

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107-2122-EXP

Identifier Type: -

Identifier Source: org_study_id

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