Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-05

Study Completion Date

2028-07-31

Brief Summary

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The Inserm NeuroPresage team has been using MRI for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of cognitive deficits in patients, particularly in the context of neurodegenerative diseases.

Two years ago, a new 3T MRI camera was installed at the Cyceron centre. It is more efficient and should make it possible to obtain better quality images and/or to reduce the time required to acquire these images.

In this context, it seems important to test the different sequences that we classically use in our studies, or that we plan to implement in our next studies (learning and text retrieval fMRI task), in order to optimize them, with a view to integrating them in our future studies.

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Detailed Description

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Conditions

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Memory Disorders

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Healthy volunteers

Group Type OTHER

MRI sequences testing

Intervention Type OTHER

Testing different MRI sequences in order to optimize them

Interventions

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MRI sequences testing

Testing different MRI sequences in order to optimize them

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers of legal age
* Affiliation with a social security scheme or beneficiary of such a scheme
* Signing of the protocol informed consent
* For women of childbearing age or capacity, a urine pregnancy test before inclusion

Exclusion Criteria

* Protected persons in accordance with articles L. 1121-5 to L.1121-8 of the Public Health Code: protected adults, pregnant and nursing women
* Presence of contraindications to MRI examination without contrast agents injection
* Presence of a chronic neurological or psychiatric condition (including substance use disorder)
* History of brain disease (vascular, degenerative, malformative, tumour, or head trauma with loss of consciousness for more than one hour)
* Current or recent use of medications that may interfere with imaging (psychotropic drugs, antihistamines with anticholinergic action, antiparkinsonian drugs, benzodiazepines including muscle relaxants, long-term steroidal anti-inflammatory drugs, antiepileptic drugs, central painkillers)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes