Memory Imaging of Normal Aging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-08-31

Study Completion Date

2008-07-31

Brief Summary

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The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.

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Detailed Description

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The overall goals of this project are to identify consistent patterns of variance in brain function in patients at risk for Alzheimer's Disease by using APOE ε4 as a marker for disease risk. The activation Blood Oxygen Level Dependency (BOLD) signal will be compared to both resting and activation perfusion signals to assess the variability of cerebral blood flow as it relates to the BOLD signal. Each participant will be imaged on a 3T MRI scanner while performing an associate episodic memory task.

A total of 90 individuals will be recruited for this study. Participants will be non-demented, right handed, adults with or without at least one APOE ε4 allele. Groups will be split as follows: A) ages 25-39: non-ε4 (n=15); B) ages 25-39: +ε4 (n=15); C) ages 40-49: non-ε4 (n=15); D) ages 40-49: +ε4 (n=15);.E) ages 50-65: non-ε4: F) ages 50-65: +ε4 (n=15). These groups will be matched for mean age, mean years of education, gender distribution, as well as the presence or absence of a family history of AD in a first degree relative.

There will be 2 scanning sessions for each participant. Scan session #1 and Scan session #2 will be acquired within 2 weeks of each other and will take approximately one hour each.

Conditions

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Alzheimer's Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

Individuals with high risk for Alzheimer's disease

BOLD and Perfusion brain MRI

Intervention Type PROCEDURE

Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour

2

Individuals with low risk for Alzheimer's disease

BOLD and Perfusion brain MRI

Intervention Type PROCEDURE

Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour

Interventions

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BOLD and Perfusion brain MRI

Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Right-handed

Exclusion Criteria

* Major medical illnesses
* History of significant head trauma with residual cognitive deficits
* Other neurological or major psychiatric disorders such as schizophrenia, bipolar disorder, developmental learning disorder, and alcohol or substance abuse
* MRI contra-indications

Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes