Dehydration Cognition

NCT ID: NCT05916183

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-05
• Study Completion Date: 2023-12-22

Brief Summary

The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

Detailed Description

A baseline series of brain function tests will be performed. Following this, participants will complete a 24 hour fluid and water rich food restriction on the day proceeding testing. Participants will then complete moderate to high intensity exercise in a hot/humid room to achieve 5% body mass loss. Once baseline core body temperature returns to baseline levels, the series of brain function tests will be performed. Participants will then consume a sports drink equal to the volume of sweat lost over the course of a 2 hour recover period. Following this, he series of brain function tests will be performed.

Conditions

Dehydration

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dehydration and Rehydration Arm

Participants will complete exercise until 5% body mass loss, followed by ad libitum rehydration throughout 2 hours of recovery.

Group Type: EXPERIMENTAL

Fluid loss and consumption

Intervention Type: BEHAVIORAL

Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

Interventions

Fluid loss and consumption

Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy
• Recreationally active
• 18-26 years old

Exclusion Criteria

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg) or tachycardic (resting heart rate ≥ 100 bpm) during the screening visit
• Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs)
• Tobacco or nicotine use in the past six months
• Current or past musculoskeletal injury impacting physical activity
• Study physician discretion based on any other medical condition or medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 26 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

State University of New York at Buffalo

OTHER

Sponsor Role: lead

Responsible Party

Riana Pryor

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Riana R Pryor, PhD

Role: PRINCIPAL_INVESTIGATOR

University at Buffalo

Locations

University at Buffalo

Buffalo, New York, United States

Countries

United States

Other Identifiers

STUDY00007342

Identifier Type: -

Identifier Source: org_study_id