The Influence of Water and Salt Intake on Copeptin Levels During Moderate Alcohol Consumption
NCT ID: NCT03883503
Last Updated: 2019-05-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2019-02-25
2019-04-10
Brief Summary
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* Beer alone
* Beer and water
* Beer and salt (stock/bouillon)
* Water alone During the study day, copeptin, sodium, osmolality and urinary sodium/osmolality will be measured at 6 timepoints.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Beer alone
Consumption of beer (correlated for weight to reach a blood alcohol concentration of 0.8) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Beer 5%o
Weight adjusted beer to reach 0.8 blood alcohol content will be given over the time course of 1 hour to the participants
Beer and water
Consumption of beer and additional water (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of water, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Beer 8.5%o and water
Weight adjusted beer to reach 0.8 blood alcohol content and water will be given over the time course of 1 hour to the participants
Beer and stock
Consumption of beer and additional stock(correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Beer 8.5%o and stock
Weight adjusted beer to reach 0.8 blood alcohol content and stock will be given over the time course of 1 hour to the participants
Water alone
Consumption of water alone (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Water
Water equivalent to the calculated volume of beer will be given over the time course of 1 hour to the participants
Interventions
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Beer 5%o
Weight adjusted beer to reach 0.8 blood alcohol content will be given over the time course of 1 hour to the participants
Beer 8.5%o and water
Weight adjusted beer to reach 0.8 blood alcohol content and water will be given over the time course of 1 hour to the participants
Beer 8.5%o and stock
Weight adjusted beer to reach 0.8 blood alcohol content and stock will be given over the time course of 1 hour to the participants
Water
Water equivalent to the calculated volume of beer will be given over the time course of 1 hour to the participants
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of alcohol dependency
* Alcohol consumption \>2 units/day
* Active nicotine abuse
* Gluten intolerance
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, etc. of the participant
* Participation in another study with investigational drug within the 30 days preceding and during the present study
* Enrolment of the investigator, his/her family members, employees and other dependent persons
* Epileptic seizures within the last year
* BMI \<18.5 or ≥25.9kg/m2
20 Years
40 Years
MALE
Yes
Sponsors
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University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Principal Investigators
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Mirjam Christ-Crain, Prof. Dr. MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Basel, Switzerland
Locations
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University Hospital Basel
Basel, , Switzerland
Countries
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Other Identifiers
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CASCO
Identifier Type: -
Identifier Source: org_study_id
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