Micro and Nanoplastics in Greenhouse Workers: Biomarkers of Exposure and Effect

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-30

Study Completion Date

2025-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

MNPLs effects on human health are still preliminary. Workers exposed to plastic residues are exposed constantly to MNPLs. One of these jobs corresponds to greenhouse workers, that could be considered as a population highly exposed to plastics. The objective of the research is to be able to detect MNPLs on body fluids as well as their potential genotoxic and immunological damage.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Biomonitoring of Occupationally Populations Exposed to Micro and Nanoplastic

NCT06323603

Occupational Exposure Genotoxicity Damage Dna

RECRUITING

Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs

NCT05679544

Metabolic Disturbance Protein Deficiency Genotoxicity

RECRUITING NA

Exposure of Taxi Drivers to Ultrafine Particles and Black Carbon Within Their Vehicles

NCT03839537

Pulmonary Ventilation

COMPLETED NA

The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers

NCT01599845

Inadequate or Impaired Respiratory Function

UNKNOWN

TEXTO : Total EXposure To Organic Pollutants

NCT02210299

Healthy

WITHDRAWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic waste that is continuously degraded into MNPLs. Information on the MNPLs' effects on human health is still preliminary and, furthermore, the limitations in current methodologies prevent accurate exposure/risk assessment.

This observational study will obtain body samples of greenhouse workers and from a control group. That would allow optimizing specific biomarkers of human MNPLs exposure and the characterization of biomarkers of early effect that allows an association among the exposure to MNPLs and effects on human health.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Microplastics Nanoplastics Genotoxic Damage Inflammation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control

Biomonitoring studies to detect MNPLs in biological samples and study of health effects.

Determination of MNPLs levels, genotoxic damage, and immunological effects

Biomonitoring of MNPLs in biological samples of greenhouse workers and controls

Intervention Type OTHER

Detection of biomarkers of exposure and genotoxic effect in biological blood, urine, exhalated air condensate, and feces

Greenhouse workers

Biomonitoring studies to detect MNPLs in biological samples and study of health effects.

Determination of MNPLs levels, genotoxic damage, and immunological effects

Biomonitoring of MNPLs in biological samples of greenhouse workers and controls

Intervention Type OTHER

Detection of biomarkers of exposure and genotoxic effect in biological blood, urine, exhalated air condensate, and feces

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Biomonitoring of MNPLs in biological samples of greenhouse workers and controls

Detection of biomarkers of exposure and genotoxic effect in biological blood, urine, exhalated air condensate, and feces

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Working in an operating greenhouse for a period of 1 month or more
* Age over 18 years old
* Absence of chronic pathology including neoplasia
* Absence of infectious disease at the date of sample collection and for a period of more than 2 weeks
* Spanish residence

* Age over 18 years old. Matched by age, gender, and lifestyle to the exposed group.
* Absence of chronic pathology including neoplasia
* Absence of infectious disease at the date of sample collection and for a period of more than 2 weeks
* Spanish residence

Exclusion Criteria

* Participation in another clinical study
* Pregnancy
* Unsigned informed consent

* Participation in another clinical study
* Pregnancy
* Unsigned informed consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes