Sympathetic Nerve Activation Evoked by Diesel Exhaust Exposure

NCT ID: NCT02892279

Last Updated: 2018-02-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-09-30
• Study Completion Date: 2016-12-31

Brief Summary

The adverse effects of air pollution on cardiovascular and respiratory health have been demonstrated in an extensive series of epidemiological, observational and experimental studies. In the current project the investigators aim to determine whether an acute exposure to diesel exhaust causes impacts on sympathetic nervous system activation in healthy volunteers.

Detailed Description

Brief as well as chronic exposures to air pollution have been linked with increases in cardiovascular morbidity and mortality. Evidence suggests that the strongest associations between air pollution exposure and adverse cardiovascular effects are found for combustion-derived particulate matter, especially in the fine and ultrafine ranges such as is found in diesel engine emissions. Despite a greater understanding of the cardiovascular effects of air pollution, the underlying mechanism through which exposure to fine particulate air pollution alters vascular function has yet to be determined. Microneurography is a method that records nerve impulse traffic in human peripheral nerves, allowing for the assessment of sympathetic nervous activity. The current study will employed microneurography techniques to evaluate autonomic function in association with inhaled air pollution exposure in healthy human volunteers.

Conditions

Healthy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Diesel exhaust exposure

A single arm study in which first a baseline muscle sympathetic nerve activity (MSNA) is recorded with and without an exposure mask. When measurements have been secured exposure to dilute diesel exhaust will start.

Group Type: EXPERIMENTAL

Diesel exhaust exposure

Intervention Type: OTHER

Evaluation of sympathetic nervous system activity as assessed by microneurography recording during an acute exposure to dilute diesel exhaust via mask.

Interventions

Diesel exhaust exposure

Evaluation of sympathetic nervous system activity as assessed by microneurography recording during an acute exposure to dilute diesel exhaust via mask.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy (normal ECG, lung function, blood sample, clinical examination)

Exclusion Criteria

• Metabolic disease
• Cardiovascular disease
• Respiratory disease
• BMI ≥ 30
• Use of psychoactive medication
• Infection within 2 weeks of the study
• Smokers or regular snus usage

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Umeå University

OTHER

Sponsor Role: lead

Responsible Party

Jenny Bosson

MD, PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jenny Bosson, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Umeå University

Locations

Dept of Medicine, Lung and Allergy section, University Hospital

Umeå, , Sweden

Countries

Sweden

References

Rankin GD, Kabele M, Brown R, Macefield VG, Sandstrom T, Bosson JA. Acute Exposure to Diesel Exhaust Increases Muscle Sympathetic Nerve Activity in Humans. J Am Heart Assoc. 2021 May 18;10(10):e018448. doi: 10.1161/JAHA.120.018448. Epub 2021 May 4.

Reference Type: DERIVED

PMID: 33942621 (View on PubMed)

Other Identifiers

Umu-2016-57-31

Identifier Type: -

Identifier Source: org_study_id