Atrial Flutter Ablation in the iCMR

NCT ID: NCT05904548

Last Updated: 2025-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

91 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-20

Study Completion Date

2025-07-31

Brief Summary

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The VISABL-AFL clinical investigation is a prospective, single-arm, multi-center, interventional, Investigational Device Exemption (IDE) trial. The primary objectives of VISABL-AFL are to assess the safety and efficacy of radiofrequency (RF) ablation of type-I atrial flutter performed with the Vision-MR Ablation Catheter 2.0 in the iCMR environment.

Detailed Description

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Conditions

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Atrial Flutter Typical

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vision-MR Atrial Flutter Ablation

Type 1 Atrial Flutter ablation performed in the iCMR with the Vision-MR Ablation Catheter 2.0 and associated Advantage-MR EP recorder and stimulator system.

Group Type EXPERIMENTAL

RF Ablation

Intervention Type DEVICE

RF ablation for type I atrial flutter under iCMR guidance

Interventions

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RF Ablation

RF ablation for type I atrial flutter under iCMR guidance

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient indicated for type I atrial flutter ablations with at least 1 documented episode of type I atrial flutter within 6 months (180 days) of enrollment
* Patient 18 years and older

Exclusion Criteria

* Contraindications for MRI procedures
* Patients who cannot have anti-arrhythmic drugs (class I or class III) prescribed for the treatment of type I atrial flutter stopped on the day of the procedure
* Previous CTI ablation procedures
* Myocardial infarction within 60 days of enrollment
* Current unstable angina
* Cardiac surgery within 90 days of enrollment
* Any cerebral ischemic event (including transient ischemic attacks) within 6 months (180 days) of enrollment
* Thrombocytosis or thrombocytopenia
* Contraindication to anticoagulation therapy
* Currently documented intracardiac thrombus or myxoma
* Implantation of permanent leads of an implantable device in or through the right atrium within 90 days of enrollment
* Prosthetic valve through which the catheter must pass
* Interatrial baffle or patch through which the catheter must pass
* Moderate or severe tricuspid valve regurgitation or stenosis
* Uncompensated congestive heart failure
* Active systemic infection
* Pregnancy or if subject plans to become pregnant during the trial
* Uncontrolled hyperthyroidism
* Any other significant uncontrolled or unstable medical condition
* Enrollment in any concurrent study without Imricor written approval
* Life expectancy of less than or equal to 2 years (730 days) per physician opinion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imricor Medical Systems

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kate Lindborg, PhD

Role: STUDY_DIRECTOR

Imricor Medical Systems, Inc.

Locations

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Johns Hopkins University

Baltimore, Maryland, United States

Site Status RECRUITING

l'institut Cardiologique Paris Sud (ICPS)

Massy, , France

Site Status RECRUITING

Amsterdam University Medical Center (UMC)

Amsterdam, , Netherlands

Site Status RECRUITING

University Hospital of Vaud (CHUV)

Lausanne, , Switzerland

Site Status RECRUITING

Countries

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United States France Netherlands Switzerland

Central Contacts

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Kate Lindborg, PhD

Role: CONTACT

9528188400

Facility Contacts

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Aravindan Kolandaivelu, MD

Role: primary

Laurent Fiorina, MD

Role: primary

Cornelis Allaart

Role: primary

Juerg Schwitter, MD

Role: primary

Other Identifiers

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VISABL-AFL

Identifier Type: -

Identifier Source: org_study_id

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