Clinical Evaluation of Therapy™ Cool Path™ Duo Cardiac Ablation System for the Treatment of Typical Atrial Flutter (AFL)

NCT ID: NCT00984204

Last Updated: 2019-02-19

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

188 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2012-01-31

Brief Summary

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The purpose of this study is to demonstrate that ablation with the Therapy™ Cool Path™ Duo cardiac ablation system can eliminate typical atrial flutter and that its use does not result in an unacceptable risk of serious adverse events (SAE's).

Detailed Description

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This is a prospective, multi-center, non-randomized study (historical data as control) for the evaluating the safety and efficacy of Therapy TM Cool PathTM

Duo Ablation System for the treatment of typical atrial flutter (Cavo-triscupid isthmus dependent)

Conditions

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Typical Atrial Flutter

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment arm

Group Type EXPERIMENTAL

Therapy Cool Path Duo

Intervention Type DEVICE

All patients will be treated with Therapy Cool Path Duo Ablation System for the treatment of typical atrial flutter.

Interventions

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Therapy Cool Path Duo

All patients will be treated with Therapy Cool Path Duo Ablation System for the treatment of typical atrial flutter.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* A signed written Informed Consent
* Presence of typical atrial flutter (cavotricuspid isthmus dependent)
* If subjects are receiving antiarrhythmic drug therapy (Class I or Class III AAD)for an arrhythmia other than typical atrial flutter, then the subject needs to be controlled on their medication for at least 3 months. If the subject had typical atrial flutter before starting the AAD(s) (Class I or Class III) and then subsequently had another arrhythmia (i.e. atrial fibrillation), then the 3 month AAD criteria will not apply.
* One documented occurrence of the study arrhythmia documented by ECG, Holter, telemetry strip, or transtelephonic monitor within the past 6 months
* In good physical health
* 18 years of age or older
* Agree to comply with follow-up visits and evaluation

Exclusion Criteria

* Prior typical atrial flutter ablation treatment
* Pregnancy
* Atypical flutter or scar flutter(non-isthmus dependent)
* Significant coronary heart disease or heart failure; that is unstable angina pectoris and/or uncontrolled congestive heart failure (NYHA Class III or IV) at the time of enrollment
* A recent myocardial infarction within 3 months of the intended procedure date
* Permanent coronary sinus pacing lead
* Tricuspid valvular disease requiring surgery and/or a prosthetic tricuspid heart valve (i.e. significant)
* Evidence of intracardiac thrombus or a history of clotting disorders
* Participation in another investigational study
* Cardiac surgery within 1 month of the intended procedure date
* Allergy or contraindication to Heparin
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Regional Cardiology Associates

Sacramento, California, United States

Site Status

Kansas University Medical Center

Kansas City, Kansas, United States

Site Status

Central Baptist Hospital

Lexington, Kentucky, United States

Site Status

Ochsner Medical Center

New Orleans, Louisiana, United States

Site Status

Washington Adventist Hospital

Takoma Park, Maryland, United States

Site Status

Lahey Clinic Medical Center

Burlington, Massachusetts, United States

Site Status

University of Rochester

Rochester, New York, United States

Site Status

Carolinas Medical Center

Charlotte, North Carolina, United States

Site Status

Moses Cone Hospital

Greensboro, North Carolina, United States

Site Status

Ohio State Medical

Columbus, Ohio, United States

Site Status

Cardiovascular Associates of Cleveland

Mayfield Heights, Ohio, United States

Site Status

Providence St. Vincent Medical Center

Portland, Oregon, United States

Site Status

Doylestown Hospital

Doylestown, Pennsylvania, United States

Site Status

Main Line Health Center/Lankenau

Wynnewood, Pennsylvania, United States

Site Status

Baylor Jack and Jane Hamilton Heart and Vascular Hospital

Dallas, Texas, United States

Site Status

St. Luke's Episcopal Hospital

Houston, Texas, United States

Site Status

The Methodist Hospital

Houston, Texas, United States

Site Status

Scott & White Memorial Hospital

Temple, Texas, United States

Site Status

Virginia Hospital Center

Arlington, Virginia, United States

Site Status

University of Virginia Medical Center

Charlottesville, Virginia, United States

Site Status

Victoria Cardiac Arrhythmia Trials, Inc.

Victoria, British Columbia, Canada

Site Status

Institut de Cardiologie de Quebec

Québec, , Canada

Site Status

Countries

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United States Canada

Other Identifiers

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90030638

Identifier Type: -

Identifier Source: org_study_id

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