Effect of Ketogenic Diet on Muscle Hypertrophy

NCT ID: NCT05897567

Last Updated: 2024-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-20

Study Completion Date

2025-12-31

Brief Summary

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The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.

Detailed Description

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Conditions

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Healthy Nutrition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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ketogenic diet

Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).

Group Type EXPERIMENTAL

resistance training

Intervention Type OTHER

All participants perform a four-day resistance training aimed to stimulate a hypertrophic response.

ketogenic diet

Intervention Type OTHER

Subjects allocated to the ketogenic diet arm (KD group) consume less than 50 g of carbohydrates per day.

western diet

Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).

Group Type ACTIVE_COMPARATOR

resistance training

Intervention Type OTHER

All participants perform a four-day resistance training aimed to stimulate a hypertrophic response.

western diet

Intervention Type OTHER

Subjects allocated to the western diet arm (WD group) consume a standard diet based on 55% of their daily calories from carbohydrates.

Interventions

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resistance training

All participants perform a four-day resistance training aimed to stimulate a hypertrophic response.

Intervention Type OTHER

ketogenic diet

Subjects allocated to the ketogenic diet arm (KD group) consume less than 50 g of carbohydrates per day.

Intervention Type OTHER

western diet

Subjects allocated to the western diet arm (WD group) consume a standard diet based on 55% of their daily calories from carbohydrates.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* at least 2 years of resistance-training experience
* Body mass index: more than 18 kg/m2 and less than 30 kg/m2

Exclusion Criteria

* metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc)
* experience with the ketogenic diet (last six months)
* acute inflammatory status
* treatment with steroids in the past 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Padova

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Antonio Paoli, MD

Role: PRINCIPAL_INVESTIGATOR

University of Padova

Locations

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Nutex LAB

Padua, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Giuseppe Cerullo

Role: CONTACT

+00393200218377

Facility Contacts

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Antonio Paoli, MD

Role: primary

+390498275318

Other Identifiers

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KETO-EX

Identifier Type: -

Identifier Source: org_study_id

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