The Effect of Supplementation of Vitamin D3 on Inflammation Induced by 100 km Running, Iron Metabolism and Erythropoiesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-19

Study Completion Date

2022-12-31

Brief Summary

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A group of runners received vitamin D (10,000 IU - international unit per day) for two weeks. The aim of the intervention was to check the effect of vitamin D supplementation on selected parameters of inflammation and iron metabolism in comparison with the placebo group. Blood was collected before and after supplementation. Next: before, after 25, 50, 75,100 km running and 12 hours after the run. The data were subjected to statistical analysis.

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Detailed Description

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Subjects were randomized to two groups: the experimental one, n = 20 and the placebo one, n = 20 with the same age, experience in running and 25(OH)D level. The experimental group received vitamin D3 supplementation (around 10,000 UI/day, i.e., 20 droplets -Vigantol medicament, Merck) and the control group received a placebo (20 droplets of sunflower oil, placed in an identical bottle as vitamin D3) for two weeks before a run. The last vitamin D dose was taken 24 h before the 100 km ultra-marathon. 40 male athletes took part in the 100 km ultra-marathon. Blood was collected before (day 0) and after supplementation (day 14). Next (day 15): before, after 25, 50, 75,100 km running and 12 hours after the run (day 16). The data were subjected to statistical analysis.

Conditions

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Inflammation; Muscle Iron Metabolism Ineffective Erythropoiesis Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Both groups took drops from the same dark bottles, 20 drops per day for two weeks.

Study Groups

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Vitamin D

Vigantol 10 000 IU/day (20 droplets) two weeks supplementation (vitamin D3)

Group Type ACTIVE_COMPARATOR

Cholecalciferol

Intervention Type DRUG

cholecalciferol 10000 UI

Control

sunflower oil, (20 droplets) two weeks supplementation.

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type OTHER

sunflower oil

Interventions

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Cholecalciferol

cholecalciferol 10000 UI

Intervention Type DRUG

placebo

sunflower oil

Intervention Type OTHER

Other Intervention Names

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Vitamin D3

Eligibility Criteria

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Inclusion Criteria

* male
* athletes running ultra-marathons

Exclusion Criteria

* vitamin D3 supplementation
* multivitamin and iron supplementation
* serum 25(OH)D low \< 10 ng/mL
* serum 25(OH)D high \> 100 ng/mL
* haemoglobin \< 10 g/dL
* other (sports injury, tournament)

Minimum Eligible Age

28 Years

Maximum Eligible Age

64 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes