Effect of Vitamin D Supplementation on Muscle Mass and Function

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Study Completion Date

2010-02-28

Brief Summary

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The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.

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Detailed Description

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The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. It was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 IU/day vitamin D or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.

Conditions

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Obesity Insulin Resistance Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Vitamin D

Participants in this arm consumed a 4000 IU vitamin D supplement daily for 12 weeks while participating in a resistance exercise training program.

Group Type EXPERIMENTAL

Vitamin D

Intervention Type DIETARY_SUPPLEMENT

4000 IU of vitamin D per day for 12 weeks.

Placebo

Participants in this arm consumed a placebo (microcrystalline cellulose) daily for 12 weeks while participating in a resistance exercise training program.

Group Type PLACEBO_COMPARATOR

Vitamin D

Intervention Type DIETARY_SUPPLEMENT

4000 IU of vitamin D per day for 12 weeks.

Placebo

Intervention Type DRUG

Placebo (microcrystalline cellulose) ingestion each day for 12 weeks.

Interventions

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Vitamin D

4000 IU of vitamin D per day for 12 weeks.

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo (microcrystalline cellulose) ingestion each day for 12 weeks.

Intervention Type DRUG

Other Intervention Names

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cholecalciferol microcrystalline cellulose

Eligibility Criteria

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Inclusion Criteria

* Physical activity scores in the "low" to "very low" category
* Fitness estimations in the "below average" or lower categories
* body mass index scores \>24.9 indicating overweight or obesity.

Exclusion Criteria

* Use of tanning booths or other artificial UV light exposure
* High baseline vitamin D and calcium intake
* Plans to visit sunny/warm destinations during the winter months/study period
* History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation
* Use of drugs to treat obesity (last 12 weeks)
* Use of over the counter anti-obesity agents (last 12 weeks)
* Recent initiation of an exercise program (last four weeks).

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes