Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2014-09-30
2018-03-01
Brief Summary
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Detailed Description
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Following screening and informed consent process a physical activity questionnaire will be administered. A blood draw will then be conducted at baseline, midpoint and endpoint. Collected blood for the purposes of this study will assess vitamin D status (25(OH)D), parathyroid hormone, ionized calcium, insulin, and a comprehensive metabolic panel. At baseline and endpoint muscle lipid will be assessed using Magnetic Resonance Spectroscopy and muscle oxygen consumption will be determined using a novel hybrid diffuse optical instrument consisting of a near-infrared spectroscopy and a diffuse correlation spectroscopy. In addition, at each study time point 3 dietary recalls will be completed and physical activity will be measured using an accelerometer.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
OTHER
QUADRUPLE
Study Groups
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vitamin D + aerobic training
vitamin D capsules every weekday (10,000IU/day) and exercise
vitamin D
50,000IU/wk of vitamin D3
aerobic training
7 days of treadmill training during the 13th week of study
vitamin D + no aerobic training
vitamin D capsules every weekday (10,000IU/day) and no exercise
vitamin D
50,000IU/wk of vitamin D3
placebo + aerobic training
placebo capsule every weekday and exercise
aerobic training
7 days of treadmill training during the 13th week of study
placebo + no aerobic training
placebo capsule every weekday and no exercise
No interventions assigned to this group
Interventions
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vitamin D
50,000IU/wk of vitamin D3
aerobic training
7 days of treadmill training during the 13th week of study
Eligibility Criteria
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Inclusion Criteria
* BMI: 18.5-29
* Communicates fluently in English
Exclusion Criteria
* Any form of hormone replacement therapy
* Engage in more than 1 hr/week of vigorous activity
* Participated in a high-intensity resistance or aerobic training program in the last 3 months
* Lower extremity injury or surgery in the past 3 months
* Foot sores or bone conditions severely limiting ability to move or perform exercise or joint pain made worse by mild exercise
* Diabetes, inflammatory bowel disease, renal disease or uncontrolled hypertension.
* Currently have or had a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise
* History of myopathy (including congenital myopathies)
* History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
* Past medical history of hyperparathyroidism, kidney stones or rhabdomyolysis
* Currently receiving treatment for vitamin D deficiency
* Vitamin D level \>30ng/mL
* Currently smoking
60 Years
ALL
Yes
Sponsors
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David Travis Thomas
OTHER
Responsible Party
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David Travis Thomas
Assistant Professor
Principal Investigators
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D. Travis Thomas, Ph.D., RD
Role: PRINCIPAL_INVESTIGATOR
University of Kentucky
Locations
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University of Kentucky
Lexington, Kentucky, United States
Countries
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Other Identifiers
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