Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2015-06-30

Brief Summary

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This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

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Detailed Description

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Conditions

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Vitamin D Deficiency

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Low 25(OH)D

We will recruit individuals with low 25(OH)D (\<30ng/mL).

Group Type OTHER

7 continuous days of aerobic training

Intervention Type OTHER

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

High 25(OH)D

We will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the "low 25(OH)D group).

Group Type OTHER

7 continuous days of aerobic training

Intervention Type OTHER

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Interventions

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7 continuous days of aerobic training

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 65-75 years of age

Exclusion Criteria

* Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
* Uncontrolled diabetes or hypertension.
* History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
* History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
* Have a diagnosis of osteoporosis (as determined by DXA)
* Participated in a resistance or aerobic training program in the last 3 months
* Engage in more than 1 hr/week of vigorous activity
* Body mass index \>29
* On hormone replacement therapy

Minimum Eligible Age

65 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes