The Effect of a Meal on Vitamin D Absorption

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

62 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2012-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study seeks to determine if vitamin D3 absorption in healthy adults will be enhanced in the presence of a meal and if the enhancement will be greater when the meal is low as opposed to high in fat content. The enhancement will result from increased vitamin D absorption. The investigators will test this hypothesis by pursuing the following aims in a 3-mo trial in which up to 70 healthy men and women will be randomized to one of the following meal conditions under which they will take a monthly oral dose of 50,000 IU of vitamin D3: no meal (fasting), a low fat meal, or a high fat meal. The Primary Aim is to identify the meal condition (fasting, low-fat, or high-fat meal) under which the 25OHD3 response to supplemental vitamin D3 is greatest and most consistent. The Secondary Aim is to determine whether vitamin D3 absorption is affected by the meal condition and to determine whether the absorption of vitamin D3 predicts the longer-term 25OHD3 response to supplementation.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Pilot Study of the Effect of Dietary Fat Type and Amount on Vitamin D3 Absorption

NCT01508845

Vitamin D Deficiency

COMPLETED NA

Efficacy of Daily Vitamin D3 Supplementation in Normal Weight Adolescents

NCT01058720

Vitamin D Deficiency

COMPLETED PHASE4

Clinical Approaches to Correcting Vitamin D Inadequacy and Maintaining Adequacy

NCT00692120

Vitamin D Inadequacy Vitamin D Deficiency

COMPLETED NA

The Effect of Fat on Vitamin D Absorption

NCT01519986

Vitamin D Deficiency

COMPLETED NA

Vitamin D3 Supplementation Pilot Study

NCT01546103

Vitamin D Deficiency

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Vitamin D supplements are increasingly recommended to curb widespread deficiency. Decreasing the variability in 25OHD responses to supplemental vitamin D would make the supplementation process more predictable, and thereby reduce the number of 25OHD measurements and dose adjustments that are needed to achieve the targeted 25OHD level. This study seeks to identify potential sources of variability in the 25OHD3 response to supplemental vitamin D3 that are plausible based on rat studies, but have not been explored in humans. The investigators hypothesize that the serum 25OHD3 response to supplemental vitamin D3 in healthy adults will be enhanced in the presence of a meal and the enhancement will be greater when the meal is low as opposed to high in fat content. The enhancement will result from increased vitamin D absorption. The investigators will test this hypothesis by pursuing the following aims in a 3-mo trial in which up to 70 healthy men and women will be randomized to one of the following meal conditions under which they will take a monthly oral dose of 50,000 IU of vitamin D3: no meal (fasting), a low fat meal, or an iso-caloric high fat meal. Serum 25OHD3 will be measured at baseline and after 1 and 3 mo. A serum vitamin D3 absorption test will be performed in each subject after the first dose of vitamin D. The Primary Aim is to identify the meal condition (fasting, low-fat, or high-fat meal) under which the 25OHD3 response to supplemental vitamin D3 is greatest and most consistent. The Secondary Aim is to determine whether vitamin D3 absorption is affected by the meal condition and to determine whether the absorption of vitamin D3 predicts the longer-term 25OHD3 response to supplementation.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vitamin D Deficiency

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Low fat meal

Those subjects who receive a low fat meal prior to vitamin D3 administration

Group Type ACTIVE_COMPARATOR

cholecalciferol

Intervention Type DIETARY_SUPPLEMENT

50,000 IU once per month for 3 months

High fat meal

Those subjects who receive a high fat meal prior to vitamin D3 administration

Group Type ACTIVE_COMPARATOR

cholecalciferol

Intervention Type DIETARY_SUPPLEMENT

50,000 IU once per month for 3 months

No meal

Those subjects who do not receive a meal and continue to fast. They only receive the vitamin D3 dose.

Group Type ACTIVE_COMPARATOR

cholecalciferol

Intervention Type DIETARY_SUPPLEMENT

50,000 IU once per month for 3 months

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

cholecalciferol

50,000 IU once per month for 3 months

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

vitamin D3

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Ages 50 to 69
* BMI ≥ 18.5 and ≤ 27.9 kg/m2
* those taking ≤ 400 IU/day of vitamin D3 and ≤ 1000 mg calcium/day
* those who participate must agree not to change their dietary or supplemental vitamin D or calcium intake during the study
* no use of tanning salons
* no travel south of latitude 34 degrees north during the study

Exclusion Criteria

General:

1. A screening 25OHD level ≤8 or ≥ 25 ng/ml
2. An abnormal serum calcium (reference range is 8.3 -10.2 mg/dl)
3. A screening spot urinary calcium:creatinine ratio \> 0.325
4. Greater than 2 drinks of alcohol a day.
5. BMI \<18.5 and \>27.9 kg/m2
6. Menses within the last year (women)
7. Age \<50 and \> 69 years
8. Allergy to egg
9. A blood donation in the last 2 months (increases likelihood of anemia)
10. Non-English speaking subjects will not be enrolled.
11. Other abnormalities in screening labs, at the discretion of the study physician (PI)

Medications:

1. Subjects must agree not to take more than 400 IU per day of vitamin D as supplement or cod liver oil during the study
2. Topical vitamin D preparations
3. Oral estrogen or estrogen patch use in the last 6 months
4. Regular antacid use (\>2 times per week)
5. Sucralfate
6. Acarbose/miglitol
7. PPIs - prescription: lansoprazole (Prevacid), omeprazole (Prilosec and Zegerid), esomeprazole (Nexium), rabeprazole (Aciphex), pantoprazole (Protonix); over-the-counter: lansoprazole (Prevacid 24), omeprazole (Prilosec OTC), zegerid OTC (Equate), omeprazole magnesium
8. H2 blockers - prescription: cimetidine (Tagamet), famotidine (Pepsid), nizatidine (Axid), rantidine hydrochloride (Zantac), dexlansoprazole (Kapidex); over the counter: cimetidine (Tagamet-HB, Equate), famotidine (Pepcid-AC, Pepcid Complete), rantidine hydrochloride (Zantac, Wal-Zan, Equate)
9. Drugs that alter fat and cholesterol handling - xenical and alli (Orlistat), cholestyramine (Questran, LoCholest, Prevalite), Zetia
10. Drugs that alter 25OHD metabolism - Antiseizure drugs phenobarbitol and phenytoin (Dilantin), oral glucocorticoids
11. Calcium supplement use \>1000 mg/day

Diseases:

1. Active parathyroid disease
2. Sarcoidosis
3. Peptic ulcers or esophageal stricture
4. Active malignancy (other than basal cell cancer of the skin) or cancer therapy in the last year
5. Advanced kidney disease (creatinine clearance \<30 ml/min calculated from serum creatinine with use of the Modification of Diet in Renal Disease (MDRD) Study equation
6. Kidney stones in the last 5 years.
7. Liver disease
8. Zollinger-Ellison syndrome
9. Known achlorhydria or small bowel overgrowth
10. Malabsorption
11. Diseases associated with fat malabsorption - liver disease, cystic fibrosis, Celiac disease, bariatric surgery, Scleroderma, Crohn's, prior surgery involving the stomach or small bowel (appendectomy okay), gall stones or prior gall bladder surgery, pancreatitis

Minimum Eligible Age

50 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes