Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
44 participants
INTERVENTIONAL
2023-12-20
2026-04-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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NPU
Participant will be presented with a series of images (cues) and sounds. Three conditions will occur - a no shock (N), predictable shock (P), and unpredictable shock (U). In P, shocks will only occur with the cue. In U, shocks will happen at any time. Participants will be told which condition they are in throughout the task. Startle sounds will occur throughout. 3 Study visits will occur - identical conditions for the participant, testing 2 brain regions and 1 sham visit.
Low-intensity focused ultrasound
A noninvasive brain stimulation device using low-intensity focused ultrasound (LIFU) - ultrasound will be used to test whether noninvasive brain stimulation can reduce reactions to sensory stimuli.
Low-intensity focused ultrasound - sham
A sham condition that will mimic the application of LIFU without actually administering any ultrasound to the brain.
NPU-c
Participants will be presented with a moving line. When the line reaches a certain point - an event will occur. This event will either be a painful shock or a monetary reward. Startle sounds will occur throughout. 3 study visits will occur - identical conditions for the participant, testing 2 brain regions and 1 sham visit.
Low-intensity focused ultrasound
A noninvasive brain stimulation device using low-intensity focused ultrasound (LIFU) - ultrasound will be used to test whether noninvasive brain stimulation can reduce reactions to sensory stimuli.
Low-intensity focused ultrasound - sham
A sham condition that will mimic the application of LIFU without actually administering any ultrasound to the brain.
Interventions
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Low-intensity focused ultrasound
A noninvasive brain stimulation device using low-intensity focused ultrasound (LIFU) - ultrasound will be used to test whether noninvasive brain stimulation can reduce reactions to sensory stimuli.
Low-intensity focused ultrasound - sham
A sham condition that will mimic the application of LIFU without actually administering any ultrasound to the brain.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Contraindications to MRI (implants)
* Contraindications to CT (pregnancy)
* Active medical disorder with CNS effects (e.g. Alzheimers)
* History of neurologic disorder (e.g. Parkinson's, epilepsy)
* History of head injury w/ LOC for \>10 min
* History of alcohol or drug dependence
* History of current cardiovascular disease
18 Years
65 Years
ALL
Yes
Sponsors
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Virginia Polytechnic Institute and State University
OTHER
Responsible Party
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Wynn Legon
Assistant Professor
Locations
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Fralin Biomedical Research Institute at VTC
Roanoke, Virginia, United States
Countries
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Other Identifiers
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23-192
Identifier Type: -
Identifier Source: org_study_id
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