Investigation of the Duration of Low-intensity Focused Ultrasound
NCT ID: NCT05147103
Last Updated: 2025-07-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
80 participants
INTERVENTIONAL
2022-08-26
2026-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Duration Trials
Six different durations (three intermittent and three continuous) of LIFU application will be tested across six study sessions. Response recorded using TMS and EMG.
Low-Intensity Focused Ultrasound
LIFU application using various durations, responses of neuromodulation recorded using TMS and EMG.
Interventions
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Low-Intensity Focused Ultrasound
LIFU application using various durations, responses of neuromodulation recorded using TMS and EMG.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1. Claustrophobia
2. Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
3. Pregnancy
4. Active medical disorder or treatment with potential CNS effects
5. History of neurologic disorder
6. History of head injury resulting in loss of consciousness for \>10 minutes
7. History of alcohol or drug dependence
18 Years
65 Years
ALL
Yes
Sponsors
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Virginia Polytechnic Institute and State University
OTHER
Responsible Party
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Wynn Legon
Assistant Professor
Locations
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Fralin Biomedical Research Institute
Roanoke, Virginia, United States
Countries
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References
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Legon W, Bansal P, Tyshynsky R, Ai L, Mueller JK. Transcranial focused ultrasound neuromodulation of the human primary motor cortex. Sci Rep. 2018 Jul 3;8(1):10007. doi: 10.1038/s41598-018-28320-1.
Legon W, Ai L, Bansal P, Mueller JK. Neuromodulation with single-element transcranial focused ultrasound in human thalamus. Hum Brain Mapp. 2018 May;39(5):1995-2006. doi: 10.1002/hbm.23981. Epub 2018 Jan 29.
Legon W, Sato TF, Opitz A, Mueller J, Barbour A, Williams A, Tyler WJ. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci. 2014 Feb;17(2):322-9. doi: 10.1038/nn.3620. Epub 2014 Jan 12.
Other Identifiers
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21-892
Identifier Type: -
Identifier Source: org_study_id
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