Investigation of Low-intensity Focused Ultrasound Parameters
NCT ID: NCT05134233
Last Updated: 2025-01-23
Study Results
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View full resultsBasic Information
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COMPLETED
NA
23 participants
INTERVENTIONAL
2022-01-14
2024-03-11
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Parameter Trials
Approximately 36 parameter combinations will be tested per study session, expected 6 sessions of trials. Response recorded using TMS and EMG.
Low-intensity Focused Ultrasound
LIFU application using various parameters, responses of neuromodulation recorded using TMS and EMG.
Interventions
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Low-intensity Focused Ultrasound
LIFU application using various parameters, responses of neuromodulation recorded using TMS and EMG.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1. Claustrophobia
2. Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
3. Pregnancy
4. Active medical disorder or treatment with potential CNS effects
5. History of neurologic disorder
6. History of head injury resulting in loss of consciousness for \>10 minutes
7. History of alcohol or drug dependence
8. Failure to provide a social security number or tax ID number. This is required for tax purposes or payment cannot be processed.
18 Years
65 Years
ALL
Yes
Sponsors
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Virginia Polytechnic Institute and State University
OTHER
Responsible Party
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Wynn Legon
Assistant Professor
Locations
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Fralin Biomedical Research Institute
Roanoke, Virginia, United States
Countries
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References
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Legon W, Bansal P, Tyshynsky R, Ai L, Mueller JK. Transcranial focused ultrasound neuromodulation of the human primary motor cortex. Sci Rep. 2018 Jul 3;8(1):10007. doi: 10.1038/s41598-018-28320-1.
Fomenko A, Chen KS, Nankoo JF, Saravanamuttu J, Wang Y, El-Baba M, Xia X, Seerala SS, Hynynen K, Lozano AM, Chen R. Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior. Elife. 2020 Nov 25;9:e54497. doi: 10.7554/eLife.54497.
Xia X, Fomenko A, Nankoo JF, Zeng K, Wang Y, Zhang J, Lozano AM, Chen R. Time course of the effects of low-intensity transcranial ultrasound on the excitability of ipsilateral and contralateral human primary motor cortex. Neuroimage. 2021 Nov;243:118557. doi: 10.1016/j.neuroimage.2021.118557. Epub 2021 Sep 4.
Provided Documents
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Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Other Identifiers
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21-882
Identifier Type: -
Identifier Source: org_study_id
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