Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation
NCT ID: NCT02594306
Last Updated: 2016-02-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2015-10-31
2016-11-30
Brief Summary
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Detailed Description
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Assessment for psychological craving degree of addiction patients is also a difficult thing.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Non operation
Recording the event related potential of drug addicts when they receive the stimulus of Emotional pictures stimulation system.
Emotional pictures stimulation system
Emotional pictures stimulation system is component of neutral and drug-related images.
Deep brain stimulation
Recording the event related potential after the deep brain stimulation operation.Recording the local field potential of drug addiction people when we conduct a test of adjacent contact stimulation in the deep brain stimulation operation. Recording the waveform of bilateral NAc/ALIC after puting the microelectrodes into bilateral nucleus accumbens and anterior limb of the internal capsule
Emotional pictures stimulation system
Emotional pictures stimulation system is component of neutral and drug-related images.
Deep brain stimulation
Deep brain stimulation of bilateral NAc/ALIC
adjacent contact stimulation
The electrode of deep brain stimulation has four contacts.We stimulate one contact,and record the local field potential of other contacts.
microelectrode
We put the microelectrodes into bilateral nucleus accumbens and anterior limb of the internal capsule,to record the waveform of bilateral NAc/ALIC.
Standard Control
Recording the event related potential of normal people when they receive the stimulus of emotional pictures stimulation system.
Emotional pictures stimulation system
Emotional pictures stimulation system is component of neutral and drug-related images.
Interventions
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Emotional pictures stimulation system
Emotional pictures stimulation system is component of neutral and drug-related images.
Deep brain stimulation
Deep brain stimulation of bilateral NAc/ALIC
adjacent contact stimulation
The electrode of deep brain stimulation has four contacts.We stimulate one contact,and record the local field potential of other contacts.
microelectrode
We put the microelectrodes into bilateral nucleus accumbens and anterior limb of the internal capsule,to record the waveform of bilateral NAc/ALIC.
Eligibility Criteria
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Inclusion Criteria
2. Opiate addictive over 3 years；
3. Physical detoxification completed（keep abstinent for at least 7 days，acute abstinent syndrome disappeared，morphine urinalysis and naloxone test showed negative)；
4. No obvious neuropsychiatry and personality disorders；
5. No severe infectious disease；
6. Good compliance and be able to complete follow up；
7. General health is good，no severe liver、kidney、heart and lung disease；
8. Informed consent issued
Exclusion Criteria
2. History of severe neuropsychiatric disease；
3. Epilepsy；
4. severe liver、kidney、heart and lung disease, severe hypertension and severe orthostatic hypotension；
5. Malignant tumor；History of brain trauma；Pregnant female；
6. Patients are taking part in other clinical trials in recent 3 months；
7. Being deem as unfit for the trials by researcher.
18 Years
50 Years
ALL
Yes
Sponsors
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Tang-Du Hospital
OTHER
Responsible Party
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Guodong Gao
Neurosurgery Department
Principal Investigators
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Guo-dong Gao, M.D.
Role: STUDY_CHAIR
Department of neurosurgery, Tangdu Hospital
Locations
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Department of neurosurgery, Tangdu Hospital
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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EEG/ERP and drug addiction
Identifier Type: -
Identifier Source: org_study_id
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