Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients
NCT ID: NCT05839821
Last Updated: 2023-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
72 participants
OBSERVATIONAL
2023-06-01
2026-03-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Methods and analysis This study will recruit patients with PD and healthy controls. Electroencephalography (EEG) will be used under six conditions related to a finger-tapping task. Two-way repeated measures analysis of variance will be performed to investigate the group and condition effects on neural mechanisms.
Study significance This study will offer evidence on RAS effects and mechanisms by investigating the changes in upper-limb movements and neural mechanisms during auditory-motor entrainment. Results from this study will provide a solid foundation for further research and clinical applications of RAS.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
NCT05782322
Rhythmic Auditory Stimulation on Upper-limb Movements in PD Patients
NCT05637593
The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
NCT02037451
Responders to Rhythmic Auditory Cueing in Parkinson Disease
NCT05733819
Effects of Rhythmic Auditory Cueing on Stepping in Place in Patients With Parkinson's Disease
NCT03271736
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
PD patients
Patients with Parkinson's disease
noF-noRAS
resting state, that is, without finger-tapping and without listening to RAS
F-noRAS
finger-tapping without listening to RAS
noF-100RAS
listening to RAS with the 100% of the baseline tempo and without finger-tapping
F-100RAS
finger-tapping and listening to RAS with 100 % of baseline tempo
F-105RAS
finger-tapping and listening to RAS with 105 % of baseline tempo
F-110RAS
finger-tapping and listening to RAS with 110 % of baseline tempo
Healthy controls
Healthy older adults
noF-noRAS
resting state, that is, without finger-tapping and without listening to RAS
F-noRAS
finger-tapping without listening to RAS
noF-100RAS
listening to RAS with the 100% of the baseline tempo and without finger-tapping
F-100RAS
finger-tapping and listening to RAS with 100 % of baseline tempo
F-105RAS
finger-tapping and listening to RAS with 105 % of baseline tempo
F-110RAS
finger-tapping and listening to RAS with 110 % of baseline tempo
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
noF-noRAS
resting state, that is, without finger-tapping and without listening to RAS
F-noRAS
finger-tapping without listening to RAS
noF-100RAS
listening to RAS with the 100% of the baseline tempo and without finger-tapping
F-100RAS
finger-tapping and listening to RAS with 100 % of baseline tempo
F-105RAS
finger-tapping and listening to RAS with 105 % of baseline tempo
F-110RAS
finger-tapping and listening to RAS with 110 % of baseline tempo
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* (b) the Hoehn and Yahr stage is 2 or 3, meaning that bilateral movement problems or combination with mild postural instability;
* (c) a score of Montreal Cognitive Assessment (MoCA) is equal to or higher than 21 to ensure that they understand experimental instructions;
* (d) a score of Edinburgh Handedness Inventory is above 60 to ensure that they are right-handed;
* (e) types and doses of medications remain unchanged in the past month right before participation.
* Age- and sex-matched healthy controls who filled the criteria (c) and (d) will be recruited from communities.
Exclusion Criteria
18 Years
85 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
The Hong Kong Polytechnic University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
FAN Wei
PhD Candidate
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Wei FAN (PhD student), MSc
Role: PRINCIPAL_INVESTIGATOR
Rehabilitation Sciences
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
References
Explore related publications, articles, or registry entries linked to this study.
Fan W, Li J, Wei W, Xiao SH, Liao ZJ, Wang SM, Fong KNK. Effects of rhythmic auditory stimulation on upper-limb movements in patients with Parkinson's disease. Parkinsonism Relat Disord. 2022 Aug;101:27-30. doi: 10.1016/j.parkreldis.2022.06.020. Epub 2022 Jun 23.
Wang SM, Chan ST, Wong YL, Hsu HM, Lee CY, Check CY, Leung CK. Rhythmic auditory stimulation incorporated in training improved movements in individuals with psychotic-like experiences. Eur Arch Psychiatry Clin Neurosci. 2023 Jun;273(4):995-1005. doi: 10.1007/s00406-022-01524-3. Epub 2022 Nov 24.
Leuk JSP, Low LLN, Teo WP. An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson's Disease. Front Aging Neurosci. 2020 Aug 14;12:243. doi: 10.3389/fnagi.2020.00243. eCollection 2020.
Thaut MH, McIntosh GC, Rice RR, Miller RA, Rathbun J, Brault JM. Rhythmic auditory stimulation in gait training for Parkinson's disease patients. Mov Disord. 1996 Mar;11(2):193-200. doi: 10.1002/mds.870110213.
Koshimori Y, Thaut MH. Future perspectives on neural mechanisms underlying rhythm and music based neurorehabilitation in Parkinson's disease. Ageing Res Rev. 2018 Nov;47:133-139. doi: 10.1016/j.arr.2018.07.001. Epub 2018 Jul 10.
Dong VA, Fong KN, Chen YF, Tseng SS, Wong LM. 'Remind-to-move' treatment versus constraint-induced movement therapy for children with hemiplegic cerebral palsy: a randomized controlled trial. Dev Med Child Neurol. 2017 Feb;59(2):160-167. doi: 10.1111/dmcn.13216. Epub 2016 Aug 9.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
HongKongPU21037721r_20230220
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.