A Trial of YPEG-rhGH in Children With Short Stature

NCT ID: NCT05838885

Last Updated: 2024-01-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 78 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-02-15
• Study Completion Date: 2023-12-19

Brief Summary

To explore the dose-response relationship between pharmacokinetics and pharmacodynamics of Y- Shaped Pegylated growth hormone injection (YPEG-GH) in children with short stature (idiopathic short stature (ISS), small for gestational age (SGA), Turner syndrome (TS)).

To evaluate its tolerability, safety and efficacy and to provide evidence for dose selection and titration for future clinical development and clinical application in these population.

Conditions

Idiopathic Short Stature; Small for Gestational Age; Turner Syndrome

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

YPEG-GH low dose group

Group Type: EXPERIMENTAL

YPEG-rhGH

Intervention Type: DRUG

YPEG-rhGH, 140μg/kg, s.c., once a week, for 52 weeks

YPEG-GH high dose group

Group Type: EXPERIMENTAL

YPEG-rhGH

Intervention Type: DRUG

YPEG-rhGH, 280μg/kg, s.c., once a week, for 52 weeks

rhGH low dose group

Group Type: ACTIVE_COMPARATOR

rhGH

Intervention Type: DRUG

rhGH, 245μg/kg/week, divided into 7 subcutaneous injections, once daily, for 52 weeks

rhGH high dose group

Group Type: ACTIVE_COMPARATOR

rhGH

Intervention Type: DRUG

rhGH, 470μg/kg/week, divided into 7 subcutaneous injections, once daily, for 52 weeks

Interventions

YPEG-rhGH

YPEG-rhGH, 140μg/kg, s.c., once a week, for 52 weeks

Intervention Type: DRUG

YPEG-rhGH

YPEG-rhGH, 280μg/kg, s.c., once a week, for 52 weeks

Intervention Type: DRUG

rhGH

rhGH, 245μg/kg/week, divided into 7 subcutaneous injections, once daily, for 52 weeks

Intervention Type: DRUG

rhGH

rhGH, 470μg/kg/week, divided into 7 subcutaneous injections, once daily, for 52 weeks

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Prepubertal (Tanner I), aged older than 4 years and younger than10 years for girls and 11 years for boys.

2. Body weight: 12kg ≤ body weight ≤ 50kg.

3. For children with idiopathic short stature: a) Birth length and weight were at the 10th percentile and above of normal reference values for infants of the same gestational age and sex; b) Height at screening was 2.0 standard deviations (SD) below the mean height for chronological age and sex c) Exclude other causes such as systemic diseases, other endocrine diseases, nutritional diseases, chromosomal abnormalities, skeletal dysplasia, psycho-emotional disorders, etc. were excluded d) GH peak ≥10.0ng/ml confirmed by two different drug GH provocation tests; e) Bone age (BA)-chronological age (CA) ≤1 year.

4. For children with small for gestational age: a) Birth length and weight were at the 10th percentile and below the normal reference values for infants if the same gestational age and sex; b) Gestational age at birth ≥ 24 weeks; c) Height at screening was below -2 SD of the mean for the same age and sex, and please refer to the protocol annex 1 for height.

5. For children with Turner syndrome: a) Chromosome karyotype: 45, X; 45, X/46, XXqi; 45, X/46, XXr; 45, X/46, XX; 46, XXqi; 46, XXpi; 45, X/47, XXX; 46, XXp-; 45, X/46, XXp-; 46, XXq-; 45, x/46, XXq-; 45, X/46, XX/47, XXX, etc.; b) Having at least one specific physical characteristic: Including but not limited to low posterior hairline, facial skin nevus, neck flips, short neck, low ear position, small jaw, high palatal arch, shield chest, wide breast spacing, elbow ectropion, knee ectropion, short 4th and 5th metacarpal, nail dysplasia, scoliosis, ptosis, strabismus, cardiovascular system abnormalities such as aortic stenosis, bicuspid aortic valve, hypertension, and reproductive system abnormalities such as primary gonadal insufficiency, renal malformation, hypothyroidism and middle ear disease; c) The height at screening was below the mean -2SD of the same age and gender, and please refer to the protocol annex 1 for height.

6. Understands and signs the informed consent form voluntarily by the subject's parent(s) and/or legal guardian(s). And written assent of the subject is required if the subject is 8 years of age or older).

Exclusion Criteria

1. For children with small for gestational: confirmed or suspected Bloom syndrome.

2. For children with Turner syndrome: containing a Y chromosome or a fragment derived from a Y chromosome.

3. Children with closed epiphysis.

4. Children who diagnosed or highly suspected growth hormone deficiency (GHD), or other types of growth abnormalities: e.g., Noonan syndrome, Prader-Willi syndrome, Russell-Silver syndrome, etc.

5. Children who have previously received systemic growth-promoting therapy, including but not limited to rhGH, aromatase inhibitors, sex hormones, etc., for at least 1 month or longer.

6. Children who are now receiving or plan to receive the therapy of glucocorticoids, methylphenidate, and any other drugs that may have an effect on growth.

7. Children with abnormal values of liver and kidney function (ALT > 1.5 ULN, Cr > 1 ULN).

8. Concomitant with chronic hepatitis B, AIDS, tuberculosis, and any other chronic infectious disease.

9. Patients with severe allergic constitutions or allergic to growth hormone or its excipients such as mannitol, lysine, sodium chloride and other ingredients.

10. Patients with a previous history of malignancy or are currently suffering from active malignancy, including intracranial tumors.

11. Patients with abnormal glucose regulation (including abnormal fasting glucose and/or abnormal glucose tolerance) or diabetes.

12. Patients who are mentally ill or have a family history of mental illness.

13. Patients who are suffering from chronic systemic diseases, such as malnutrition, immunocompromised individuals, asthma, etc.

14. Patients with congenital intracranial hypertension.

15. Patients with slipped capital femoral epiphysis (SCFE).

16. Patients with scoliosis exceeding 15°;

17. Patients who have participated in any drug clinical study (as a subject) within 3 months prior to screening and have received a drug intervention

18. Patients who the investigators considered unfit for the study.

• Minimum Eligible Age: 4 Years
• Maximum Eligible Age: 11 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tongji Hospital

OTHER

Sponsor Role: collaborator

Xiamen Amoytop Biotech Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The Fourth Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

The Second Hospital of Anhui Medical University

Hefei, Anhui, China

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

The Third Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Sanya Central Hospital (Hainan Third People's Hospital)

Sanya, Hainan, China

Henan Children's Hospital Zhengzhou Children's Hospital

Zhengzhou, Henan, China

Tongji Hospital, Tongji Medical College of HUST

Wuhan, Hubei, China

Wuhan Children's Hospital

Wuhan, Hubei, China

Hunan Children's Hospital

Changsha, Hunan, China

Children's Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Children's Hospital of Soochow University

Suzhou, Jiangsu, China

Affiliated Hospital of Jiangnan University

Wuxi, Jiangsu, China

Jiangxi Provincial Children's Hospital

Nanchang, Jiangxi, China

Chengdu Women's and Children's Central Hospital

Chengdu, Sichuan, China

West China Second University Hospital, Sichuan University

Chengdu, Sichuan, China

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

Children's Hospital, Capital Institute of Pediatrics

Beijing, , China

Children's Hospital of Shanghai

Shanghai, , China

Countries

China

Other Identifiers

TB2106GH

Identifier Type: -

Identifier Source: org_study_id