Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children

NCT ID: NCT01604395

Last Updated: 2021-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

6000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2032-12-31

Brief Summary

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The purpose of this study is to evaluate the long-term safety and effectiveness of growth hormone (Eutropin Inj./Eutropin plus Inj.) treatment with GHD (Growth Hormone Deficiency), TS (Turner Syndrome),CRF (Chronic Renal Failure), SGA (Small for Gestational Age), and ISS (Idiopathic Short Stature).

Detailed Description

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Conditions

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Growth Hormone Deficiency Turner Syndrome Chronic Renal Failure Small for Gestational Age Idiopathic Short Stature

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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growth hormone

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* short stature children aged 2 years or more
* children with GHD,TS, CRF, SGA or ISS
* written informed consent from the person, person's parent or legal guardian
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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LG Chem

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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HW Chae, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kangnam severance hospital

KS Sim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kangdong KyungHee University hospital

IT Hwang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kangdong Sacred Heart Hospital

SC Chung, M.D.

Role: PRINCIPAL_INVESTIGATOR

Konkook University hospital

CW Ko, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kyungpook National University Hospital

HS Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Keimyung University hospital

YJ Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Korea University

KH Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Korea University Anam Hospital

JH Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kosin university hospital

JS Yu, M.D.

Role: PRINCIPAL_INVESTIGATOR

Dankook University

JH Yu, M.D.

Role: PRINCIPAL_INVESTIGATOR

Dong-A University Hospital

SY Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

SMG-SNU Boramae Medical Center

WY Chung, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inje University

Yl Shin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Buchun Soonchunhyang university hospital

CY Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

daejin medical center

DK Jin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

MJ Park, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inje University

CH Shin, M.D.

Role: STUDY_CHAIR

Seoul National University Hospital

BK Suh, M.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul St. Mary's Hospital

HW Yoo, M.D.

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

MH Jung, M.D.

Role: PRINCIPAL_INVESTIGATOR

Yeouide St. Mary's hospital

SH Park, M.D.

Role: PRINCIPAL_INVESTIGATOR

St Vincent's Hospital

DH Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Sowha children's hospital

DH Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul Soonchunhyang university hospital

HS Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Sinchon severance hospital

JS Hwang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Ajou University School of Medicine

SY Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Pusan National University Yangsan Hospital

JD Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Wonkwang university school of medicine & hospital

HS Han, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chungbuk National University Hospital

KH Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Wonkwang University Sanbon Medical Center

EK Yoo, M.D.

Role: PRINCIPAL_INVESTIGATOR

Bunsangcha hospital

BK Lim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Wonju Christian Hospital

JH Kang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Eulji University Hospital

JY Seo, M.D.

Role: PRINCIPAL_INVESTIGATOR

Eulji General Hospital

HS Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

ehwa university medical center

JE Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inha University Hospital

JH Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inje University

CJ Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chonnam National University Hospital

DY Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chonbuk National University Hospital

KS Shin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Jeju National University Hospital

IT Hwang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Hallym University Medical Center

SM Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Hanyang University

KH Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Korea University Guro Hospital

KS Jo, M.D.

Role: PRINCIPAL_INVESTIGATOR

Bucheon St. Mary's Hospital

SY Ahn, M.D.

Role: PRINCIPAL_INVESTIGATOR

KangWon National University Hospital

PS Oh, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chuncheon Sacred Heart Hospital

S Yang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Hallym University Kangnam Sacred Heart Hospital

EY Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chosun University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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YoungHwan Jang

Role: CONTACT

82-2-6924-3158

Facility Contacts

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CH Shin, M.D.

Role: primary

References

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Kim JH, Kim SJ, Chung IH, Lim JS. Adiposity Rebound Timing in Small for Gestational Age Children Treated With Growth Hormone: Results From LG Growth Study Data. J Korean Med Sci. 2025 Feb 3;40(4):e12. doi: 10.3346/jkms.2025.40.e12.

Reference Type DERIVED
PMID: 39901524 (View on PubMed)

Jeong HR, Lee HS, Hwang JS. Growth Prediction Model for Prepubertal Children With Idiopathic Growth Hormone Deficiency: An Analysis of LG Growth Study Data. Clin Endocrinol (Oxf). 2025 Mar;102(3):281-287. doi: 10.1111/cen.15178. Epub 2024 Dec 15.

Reference Type DERIVED
PMID: 39676465 (View on PubMed)

Lee HS, Kum CD, Rho JG, Hwang JS. Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data. PLoS One. 2022 Apr 26;17(4):e0266329. doi: 10.1371/journal.pone.0266329. eCollection 2022.

Reference Type DERIVED
PMID: 35472208 (View on PubMed)

Lim HH, Kim YM, Lee GM, Yu J, Han HS, Yu J. Growth Responses During 3 Years of Growth Hormone Treatment in Children and Adolescents With Growth Hormone Deficiency: Comparison Between Idiopathic, Organic and Isolated Growth Hormone Deficiency, and Multiple Pituitary Hormone Deficiency. J Korean Med Sci. 2022 Mar 21;37(11):e90. doi: 10.3346/jkms.2022.37.e90.

Reference Type DERIVED
PMID: 35315601 (View on PubMed)

Cho WK, Ahn MB, Kim EY, Cho KS, Jung MH, Suh BK. Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database. J Korean Med Sci. 2020 May 18;35(19):e151. doi: 10.3346/jkms.2020.35.e151.

Reference Type DERIVED
PMID: 32419399 (View on PubMed)

Other Identifiers

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LG-HGOS001

Identifier Type: -

Identifier Source: org_study_id

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