Protein Turnover in Healthy and Overuse-diseased Tendon
NCT ID: NCT05776485
Last Updated: 2024-06-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
36 participants
INTERVENTIONAL
2023-05-10
2024-05-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Chronic tendinopathy patients
Cross-sectional comparison between healthy and tendinopathic group
Comparison of primary and secondary outcomes.
Healthy controls
Progressive resistance training
Only the control group: 3 exercise bouts within the study period. Comparison between exercised and non-exercised leg.
Cross-sectional comparison between healthy and tendinopathic group
Comparison of primary and secondary outcomes.
Interventions
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Progressive resistance training
Only the control group: 3 exercise bouts within the study period. Comparison between exercised and non-exercised leg.
Cross-sectional comparison between healthy and tendinopathic group
Comparison of primary and secondary outcomes.
Eligibility Criteria
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Inclusion Criteria
* Body mass index 18,5 - 30 kg/m2
* Debut of symptom \> 90 days prior to inclusion.
* Subjective activity related pain in patella tendon.
* Clinical symptoms of patella tendinopathy.
* Ultrasound verification of at least 1 in three of the following: Enchanced anterior-posterior diameter, increased Doppler signal and/or a hypoechoic area in the diseased part of the tendon.
Exclusion Criteria
* Local injection of corticosteroids within 12 months.
* Medication that affects protein synthesis in tendon tissue.
* Former/current use of anabolic steroids or growth hormone.
* Smoking
* Known rheumatoid disease or diabetes.
* Former participation in trials using deuterated water and 15N tracers.
* Treatment for patella tendinopathy within 3 months.
18 Years
40 Years
ALL
Yes
Sponsors
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Bispebjerg Hospital
OTHER
Responsible Party
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Ann Damgaard
Medical Doctor
Principal Investigators
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Michael Kjær, Professor
Role: PRINCIPAL_INVESTIGATOR
Institute of Sports Medicine, Copenhagen
Locations
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Institute of Sports Medicine Copenhagen
Copenhagen, Capital Region, Denmark
Countries
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Other Identifiers
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Project 159
Identifier Type: -
Identifier Source: org_study_id
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