The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

NCT ID: NCT01346995

Last Updated: 2011-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2010-08-31

Brief Summary

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The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Detailed Description

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Conditions

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Muscle Strength

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Experimental Knee Pain

Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad

Group Type EXPERIMENTAL

Experimental knee pain

Intervention Type OTHER

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

Control

non-painful injections of isotonic saline into the infrapatellar fatpad.

Group Type ACTIVE_COMPARATOR

Non-painful control injections

Intervention Type OTHER

Injection of isotonic saline into the infrapatellar fat pad

Interventions

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Experimental knee pain

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

Intervention Type OTHER

Non-painful control injections

Injection of isotonic saline into the infrapatellar fat pad

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* aged between 20 to 35 years
* healthy
* untrained (non-regular exercise participation \[i.e. \< 1 day/week\])

Exclusion Criteria

* symptomatic musculoskeletal diseases
* history of traumatic injuries to muscles, tendons or joints of the lower extremity
* knee joint pain within a month prior to enrollment
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Frederiksberg University Hospital

OTHER

Sponsor Role lead

Responsible Party

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The Parker Institute

References

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Sorensen TJ, Langberg H, Hodges PW, Bliddal H, Henriksen M. Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial. Arthritis Care Res (Hoboken). 2012 Jan;64(1):108-16. doi: 10.1002/acr.20618.

Reference Type DERIVED
PMID: 21905254 (View on PubMed)

Other Identifiers

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072.07

Identifier Type: -

Identifier Source: org_study_id

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