Biopsychosocial Factors in Resistance Exercise in Individuals with Knee Pain

NCT ID: NCT06073899

Last Updated: 2024-09-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 57 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-16
• Study Completion Date: 2024-09-20

Brief Summary

The purpose of this research is to examine changes in pain sensitivity during high fatigue exercise, low fatigue exercise, and no treatment in individuals who are currently experiencing knee pain. Dosing dynamic resistance exercise intensity based on fatigue level is a novel, clinically feasible method. Dynamic resistance exercise at a high intensity (75% 1 repetition maximum (RM)) produces significant hypoalgesia at local sites compared to no treatment; however, dosing intensity based on 1RM can be challenging to implement in the clinical setting. Fatiguing endurance tasks produce local and systemic reductions in pressure pain threshold with low intensity isometric exercise completed until failure resulting in the largest exercise induced hypoalgesia effects. Fatigue may be an important mediator in pain response to exercise.

Conditions

Knee Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Quiet Rest

Participants will sit quietly for two minutes, three times. Pressure pain threshold will be measured between each two-minute interval.

Group Type: NO_INTERVENTION

No interventions assigned to this group

High Fatigue Exercise

Participants will perform a leg extension exercise in a machine with weight equipment to 65% of their 1-repetition maximum. Participants will complete this exercise for three sets until they report the exercise is "hard" (8/10 on the OMNI perceived exertion scale).

Group Type: EXPERIMENTAL

Leg Extension Exercise

Intervention Type: OTHER

Participants will perform a concentric quadriceps contraction into terminal knee extension with weight equivalent to 65% of a1-repetition maximum.

Low Fatigue Exercise

Participants will perform a leg extension exercise in a machine with weight equipment to 65% of their 1-repetition maximum. Participants will complete this exercise for three sets until they report the exercise is "somewhat easy" (4/10 on the OMNI perceived exertion scale).

Group Type: ACTIVE_COMPARATOR

Leg Extension Exercise

Intervention Type: OTHER

Participants will perform a concentric quadriceps contraction into terminal knee extension with weight equivalent to 65% of a1-repetition maximum.

Interventions

Leg Extension Exercise

Participants will perform a concentric quadriceps contraction into terminal knee extension with weight equivalent to 65% of a1-repetition maximum.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Experiencing knee pain symptom intensity rated as 3/10 or higher in the past 24 hours

Exclusion Criteria

• non-English speaking
• history of knee surgery or fracture within the past 6 months
• history of quadriceps tendon rupture
• history of a chronic pain condition, such as fibromyalgia
• systemic medical conditions that affect sensation, such as uncontrolled diabetes or neurological conditions
• blood clotting disorder, such as hemophilia
• known presence of cardiovascular, pulmonary, or metabolic disease
• current use of tobacco products
• contraindication to the application of ice, including blood pressure over 140/90 mmHg, -conditions that cause hives or blood in urine when exposed to cold, and any reductions in blood flow to arms or legs.
• not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire + (PAR-Q+)
• pain during active knee range of motion 0-90 degrees (examined during screening)
• Pregnant
• unable to attend 4 sessions

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Central Florida

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Abigail Wilson

Role: PRINCIPAL_INVESTIGATOR

University of Central Florida

Locations

University of Central Florida

Orlando, Florida, United States

Countries

United States

Other Identifiers

7

Identifier Type: -

Identifier Source: org_study_id