Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load
NCT ID: NCT03950596
Last Updated: 2019-05-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2019-05-31
2020-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
Acute resistant load exercises
Leg bench and leg press acute resistant load exercises
Leg-bench and leg-press acute resistant load exercises
Background Questionnaire
Background questionnaire will be filled out by participants
Pain Questionnaire
Pain questionnaire regarding pain in the knee during previous 3 months
DNA and RNA test
DNA and RNA tests will be sent to a genetic laboratory for analysis
Ultrasound
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
Percutaneous Needle Core Biopsy
Core Biopsy will be taken from the quadriceps femoris muscle
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Acute resistant load exercises
Leg bench and leg press acute resistant load exercises
Leg-bench and leg-press acute resistant load exercises
Background Questionnaire
Background questionnaire will be filled out by participants
Pain Questionnaire
Pain questionnaire regarding pain in the knee during previous 3 months
DNA and RNA test
DNA and RNA tests will be sent to a genetic laboratory for analysis
Ultrasound
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
Percutaneous Needle Core Biopsy
Core Biopsy will be taken from the quadriceps femoris muscle
Control Group
One hundred volunteers will participate in study as a control group
Background Questionnaire
Background questionnaire will be filled out by participants
Pain Questionnaire
Pain questionnaire regarding pain in the knee during previous 3 months
DNA and RNA test
DNA and RNA tests will be sent to a genetic laboratory for analysis
Ultrasound
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
Percutaneous Needle Core Biopsy
Core Biopsy will be taken from the quadriceps femoris muscle
Interventions
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Acute resistant load exercises
Leg bench and leg press acute resistant load exercises
Leg-bench and leg-press acute resistant load exercises
Background Questionnaire
Background questionnaire will be filled out by participants
Pain Questionnaire
Pain questionnaire regarding pain in the knee during previous 3 months
DNA and RNA test
DNA and RNA tests will be sent to a genetic laboratory for analysis
Ultrasound
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
Percutaneous Needle Core Biopsy
Core Biopsy will be taken from the quadriceps femoris muscle
Eligibility Criteria
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Inclusion Criteria
* Pass heart/lung endurance tests
* Pass ergometrics testing
Exclusion Criteria
* Had physiotherapy for back or lower limbs in past 6 months
* Orthopedic surgery in lower limbs
18 Years
30 Years
ALL
Yes
Sponsors
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Hillel Yaffe Medical Center
OTHER_GOV
Responsible Party
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Locations
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Hillel Yaffe Medical Center
Hadera, , Israel
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HYMC-58-16
Identifier Type: -
Identifier Source: org_study_id
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