Preoperative Strength Training in Patients With Total Knee Arthroplasty

NCT ID: NCT01647243

Last Updated: 2012-07-23

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 70 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-01-31
• Study Completion Date: 2013-12-31

Brief Summary

The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).

Detailed Description

Reduced strength of the quadriceps muscle is a common clinical finding in patients with Knee Osteoarthritis and this seems to play a central role in the development of the disease. The strength of the quadriceps muscle have been shown to be reduced by 20-40% as compared to age-matched healthy controls and this decrease in muscle strength have been closely associated with a reduced level of function and increase of pain. Furthermore, it has been demonstrated that the preoperative strength of the quadriceps muscle in patients undergoing TKA, is associated with the level of function one year after surgery. Compared to the level before the operation, an additional operation-induced reduction of the strength of the quadriceps muscle up to 60% as has been demonstrated. Presumably, an optimizing of the strength of the quadriceps muscle could counteract the impact of the expected postoperative loss of muscle strength to such an extent that the loss will be of less clinical significance. It is hypothesized that an optimizing of the strength of the quadriceps muscle may have a favorable effect on the postoperative rehabilitation program and shorten the period of convalescence.

Conditions

Osteoarthritis, Knee

Keywords

Knee osteoarthritis; Total knee arthroplasty; Preoperative training; Strength training

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Preoperative strength training

Progressive strength training on group basis four weeks before the operation and progressive strength training on group basis four weeks after the operation

Group Type: EXPERIMENTAL

Preoperative strength training

Intervention Type: OTHER

Progressive strength training on group basis (not more than 3 subjects) 3 sessions weekly starting 4 weeks before the operation, in total 12 sessions Strength training 3 sessions weekly 4 weeks postsurgery

Living as usual

The patients are living as usual the last 4 weeks before operation

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Preoperative strength training

Progressive strength training on group basis (not more than 3 subjects) 3 sessions weekly starting 4 weeks before the operation, in total 12 sessions Strength training 3 sessions weekly 4 weeks postsurgery

Intervention Type: OTHER

Other Intervention Names

Strength training; Preoperative training

Eligibility Criteria

Inclusion Criteria

• Planned TKA at the Aarhus University Hospital or Region Hospital Silkeborg,
• Living in Aarhus Municipality,
• Primary knee osteoarthritis or secondary osteoarthritis after meniscectomy or ligament injury

Exclusion Criteria

• Unstable blood pressure,
• Neuromuscular or neurodegenerative disease,
• Comprehension or dementia problems

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Aarhus

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Kjeld Soeballe, Professor

Role: STUDY_CHAIR

Aarhus University Hospital, Department of orthopaedic, Tage Hansensgade 2, 8000 Aarhus C

Locations

Aarhus University hospital

Aarhus, , Denmark

Site Status: RECRUITING

Countries

Denmark

Central Contacts

Birgit Sørensen Skoffer, MPH

Role: CONTACT

Phone: +45 50 42 28 30

Email: BSkoffer@dadlnet.dk

Facility Contacts

Birgit Sørensen Skoffer, MPH

Role: primary

References

Skoffer B, Dalgas U, Maribo T, Soballe K, Mechlenburg I. No Exacerbation of Knee Joint Pain and Effusion Following Preoperative Progressive Resistance Training in Patients Scheduled for Total Knee Arthroplasty: Secondary Analyses From a Randomized Controlled Trial. PM R. 2018 Jul;10(7):687-692. doi: 10.1016/j.pmrj.2017.11.002. Epub 2017 Nov 9.

Reference Type: DERIVED

PMID: 29129608 (View on PubMed)

Skoffer B, Maribo T, Mechlenburg I, Hansen PM, Soballe K, Dalgas U. Efficacy of Preoperative Progressive Resistance Training on Postoperative Outcomes in Patients Undergoing Total Knee Arthroplasty. Arthritis Care Res (Hoboken). 2016 Sep;68(9):1239-51. doi: 10.1002/acr.22825. Epub 2016 Jul 28.

Reference Type: DERIVED

PMID: 26713665 (View on PubMed)

Other Identifiers

M-20110181

Identifier Type: -

Identifier Source: org_study_id