Double Anaerobic Threshold in Athletes

NCT ID: NCT05770453

Last Updated: 2023-03-15

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-15
• Study Completion Date: 2023-12-31

Brief Summary

During an incremental cardiopulmonary exercise test (CPET) performed with a ramp protocol, it is very important to determine the anaerobic threshold, defined as the point at which the metabolism switches from being predominantly aerobic to also being anaerobic. The anaerobic threshold can be determined invasively, by identifying the increase in blood lactates with an arterial sampling, or, more commonly, non-invasively by three methods: the V-slope method, the ventilatory equivalents method and by using end-expiratory oxygen and carbon dioxide pressure (PETO2 and PETCO2 respectively). Normally, the anaerobic threshold is determined by the first method and the other two are used to confirm the value. The finding of different anaerobic threshold values using these three methods has been reported anecdotally in the past, while a prevalence of 11% in a healthy population has recently been described. Regular training, particularly that aimed at endurance sports, is able to shift the anaerobic threshold to higher exercise intensities. At present, the physiological reasons for the presence of a double threshold are unclear.

The aim of the study is to identify the anaerobic threshold by means of the V-slope method and by means of the ventilatory equivalents method in athletes who have performed an incremental ramp CPET at the laboratories of the investigating centres, to assess in how many athletes a double threshold is present and to try to interpret the physiological/ pathophysiological significance of this finding.

In this retrospective and prospective observational study, healthy male and female athletes who have had a cardiopulmonary test at our laboratories from 2007 to the present (retrospectively recruited) and prospectively recruited until the calculated sample size is reached will be enrolled.

Conditions

Cardiopulmonary Exercise Test; Anaerobic Threshold; Athlete

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: OTHER

Eligibility Criteria

Inclusion Criteria

• no major present or past illnesses, no ongoing treatment
• At least 2 training sessions per week.

Exclusion Criteria

• Current illnesses and treatments for any physical condition that could potentially alter performance
• Subjects who have performed a submaximal test (RER < 1.05)
• CPET during which the AT determination is poorly assessable, i.e. due to changes in respiration.
• obese subjects (BMI >30)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Azienda Ospedaliero-Universitaria Careggi

OTHER

Sponsor Role: collaborator

University of Foggia

OTHER

Sponsor Role: collaborator

Centro Cardiologico Monzino

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Piergiuseppe Agostoni, Prof.

Role: PRINCIPAL_INVESTIGATOR

Centro Cardiologico Monzino

Locations

Azienda Ospedaliero-Universitaria Careggi

Florence, , Italy

Site Status: RECRUITING

University of Foggia

Foggia, , Italy

Site Status: NOT_YET_RECRUITING

Centro Cardiologico Monzino

Milan, , Italy

Site Status: RECRUITING

Countries

Italy

Central Contacts

Piergiuseppe Agostoni, Prof

Role: CONTACT

piergiuseppe.agostoni@cardiologicomonzino.it

+39 0258002772

Facility Contacts

Pietro Amedeo Modesti, Prof

Role: primary

Michele Correale, MD

Role: primary

Piergiuseppe Agostoni, Prof

Role: primary

piergiuseppe.agostoni@cardiologicomonzino.it

+39 0258002010

Other Identifiers

CCM 1719

Identifier Type: -

Identifier Source: org_study_id