Effect of IV Nalbuphine on Nausea and Vomiting Following Intrathecal Morphine
NCT ID: NCT05704673
Last Updated: 2023-05-08
Study Results
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Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2023-06-01
2024-06-30
Brief Summary
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Detailed Description
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Nalbuphine is a mu receptor antagonist and a ĸappa receptor agonist.10 When added as an adjunct to intrathecal local anesthetics, it provides good analgesia with decreased incidence and severity of mu receptor side effects(3) Morphine binds most readily to the mu-opioid receptor and less well to the kappa-opioid receptor. So, the undesirable adverse events of morphine are thought to result from agonism at the mu-opioid receptor.5 Many drugs have been tried with morphine to potentiate its analgesic effects or to reduce the adverse events.6 Nalbuphine is a mixed opioid agonist-antagonist that acts mainly through kappa-opioid receptors, and it may attenuate mu-opioid receptor related side effects.3 Moreover, recent studies suggested that the analgesic effects of morphine and nalbuphine may be additive.
The addition of nalbuphine to intrathecal bupivacaine plus morphine significantly reduced the incidence and severity of postoperative nausea and vomiting and pruritus without affecting analgesic potency..(4)
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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group (1)
who given intrathecal morphine thin IV nalbuphine and asize of 80 patients
nalbuphine on N and V and pain with intrathecal morphine onInguinal hernia repair surgery. randomized, prospective, double blinded and placebo-controlled trial study.
investigate the effect of Iv nalbuphine on postoperative nausea and vomiting and pain with intrathecal morphine on inguinal hernia repair surgery.
group (2)
who given intrathecal morphine onInguinal hernia druing spinal anathesia
nalbuphine on N and V and pain with intrathecal morphine onInguinal hernia repair surgery. randomized, prospective, double blinded and placebo-controlled trial study.
investigate the effect of Iv nalbuphine on postoperative nausea and vomiting and pain with intrathecal morphine on inguinal hernia repair surgery.
Interventions
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nalbuphine on N and V and pain with intrathecal morphine onInguinal hernia repair surgery. randomized, prospective, double blinded and placebo-controlled trial study.
investigate the effect of Iv nalbuphine on postoperative nausea and vomiting and pain with intrathecal morphine on inguinal hernia repair surgery.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* males
* Scheduled patients for inguinal hernia repair surgery with under spinal anesthesia.
* ASA grade 1,2
* normal cardiac and renal function
Exclusion Criteria
* Allergy to the studied drugs.
* Patients with contraindications to spinal anesthesia
* ASA grade 3,4
15 Years
70 Years
MALE
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Rehab Marzouk Gomaa
house officer
Central Contacts
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References
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Ibrahim AS, Aly MG, Thabet ME, Abdelaziz MR. Effect of adding nalbuphine to intrathecal bupivacaine with morphine on postoperative nausea and vomiting and pruritus after elective cesarean delivery: a randomized double blinded study. Minerva Anestesiol. 2019 Mar;85(3):255-262. doi: 10.23736/S0375-9393.18.12751-9. Epub 2018 May 30.
Other Identifiers
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17101956
Identifier Type: -
Identifier Source: org_study_id
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