Sleeve-pex: A Randomized Trial to Reduce Reflux After Sleeve Gastrectomy

NCT ID: NCT05704348

Last Updated: 2024-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

550 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-04

Study Completion Date

2030-12-31

Brief Summary

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The goal of this clinical trial is to test gastropexy as a measure to reduce reflux in morbidly obese patients being submitted to sleeve gastrectomy. The main questions it aims to answer are:

Does gastropexy reduce reflux symptoms? Does gastropexy reduce objective evidence of reflux? Participants will be randomized to gastropexy or no gastropexy, and researchers will compare these groups to see if reflux (symptoms / objective evidence of) is different in the two groups.

Detailed Description

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Laparoscopic sleeve gastrectomy (LSG) has become the most commonly performed bariatric procedure worldwide. LSG consists of a longitudinal resection of the stomach leaving the intestines intact, thereby lowering the risk for side-effects due to rerouting of the small bowel. However, gastro-esopageal reflux disease (GERD) has been reported to increase after LSG. Our hypothesis is that GERD is mainly due to intrathoracic migration of the gastric remnant. The aim of this study is to explore if suturing the gastric remnant to the gastrocolic ligament (gastropexy) will prevent intrathoracic migration and thereby reduce the development of reflux.

Patients planned for a sleeve gastrectomy will be invited to participate, and participating patients will be randomized to pexi or no pexi. According to power calculations a total of 550 patients will be randomized in the study. Follow-up will be at six weeks, one-, two- and five years.

Conditions

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Gastroesophageal Reflux

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Caregivers
The patient and the healtcare workers will be masked as to whether a pexi has been performed or not.

Study Groups

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No gastropexy

Sleeve gastrectomy without gastropexy.

Group Type ACTIVE_COMPARATOR

Sleeve gastrectomy without gastropexy

Intervention Type PROCEDURE

Sleeve gastrectomy without suturing the gastric remnant to the gastrocolic ligament.

Gastropexy

Sleeve gastrectomy with gastropexy

Group Type EXPERIMENTAL

Sleeve gastrectomy with gastropexy

Intervention Type PROCEDURE

Gastropexy in this project means suturing the gastric remnant to the gastrocolic ligament.

Interventions

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Sleeve gastrectomy with gastropexy

Gastropexy in this project means suturing the gastric remnant to the gastrocolic ligament.

Intervention Type PROCEDURE

Sleeve gastrectomy without gastropexy

Sleeve gastrectomy without suturing the gastric remnant to the gastrocolic ligament.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients planned for bariatric surgery with primary LSG

Exclusion Criteria

* Age below 18 yrs
* Use of ARM for other reasons than reflux
* Previous antireflux surgery
* Inability to comprehend and respon to patient related outcome (PRO) questionnaire
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Helse Forde

OTHER

Sponsor Role lead

Responsible Party

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Villy Våge

Project leader

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Villy Vage, MD PhD

Role: STUDY_CHAIR

Helse Forde

Locations

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Helse Forde

Førde, , Norway

Site Status NOT_YET_RECRUITING

Aleris Oslo

Oslo, , Norway

Site Status RECRUITING

Volda sjukehus

Volda, , Norway

Site Status RECRUITING

Voss sjukehus

Voss, , Norway

Site Status RECRUITING

Countries

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Norway

Central Contacts

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Villy Vage, MD PhD

Role: CONTACT

47 90863744

John Andersen, PhD

Role: CONTACT

47 48278186

Facility Contacts

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Villy Våge, PhD

Role: primary

47 90863744

John Roger Andersen, PhD

Role: backup

47 48278186

Bent Johnny Nergård, MD

Role: primary

Therese Saunes, MD

Role: primary

Jonas Nedkvitne, MD

Role: primary

Other Identifiers

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421917

Identifier Type: -

Identifier Source: org_study_id

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