Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

NCT ID: NCT04411823

Last Updated: 2025-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-01

Study Completion Date

2028-10-31

Brief Summary

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Researchers are trying to identify predictors for gastroesophageal reflux disease after sleeve gastrectomy.

Detailed Description

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Subjects will undergo an upper endoscopy with EndoFLIP before sleeve gastrectomy to measure parameters from endoscopy and EndoFLIP device to develop a prediction model for post-operative gastroesophageal reflux disease. Subjects will undergo a repeat upper endoscopy with EndoFLIP at 6 months if an upper endoscopy is clinically indicated after surgery and complete questionnaires during follow-ups up to 5 years.

Conditions

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Gastroesophageal Reflux Sleeve Gastrectomy Bariatric Surgery Complication

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Intervention arm

Undergo an upper endoscopy with EndoFLIP at baseline before sleeve gastrectomy

Group Type EXPERIMENTAL

EndoFLIP measurement

Intervention Type DEVICE

EndoFLIP device can measure gastroesophageal junction distensibility index and esophageal contractile pattern under FDA cleared indication. It is performed during endoscopy.

Interventions

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EndoFLIP measurement

EndoFLIP device can measure gastroesophageal junction distensibility index and esophageal contractile pattern under FDA cleared indication. It is performed during endoscopy.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adult patients \> 18 years
* BMI 30 or greater kg/m2
* Participants can give a consent to the procedure
* Participants have no contraindications to LSG (gastric ulceration)

Exclusion Criteria

* Participants who have LA grade C or D esophagitis, Barrett mucosa or peptic stricture.
* Patients who have evidence of a major motility abnormality defined by the Chicago classification version 3.0 (achalasia, absent contractility, esophagogastric junction outflow obstruction, distal esophageal spasm, or hypertensive peristalsis)
* Patients with hiatal hernia \> 3 cm
* Patients with previous esophageal or stomach surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Omar Ghanem

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Omar Ghanem, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Orlando Health

Orlando, Florida, United States

Site Status ACTIVE_NOT_RECRUITING

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Elizabeth Lemke

Role: CONTACT

5072663317

Facility Contacts

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Abi Stromme

Role: primary

507-538-8238

Elizabeth Lemke

Role: backup

507-266-3317

Related Links

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Other Identifiers

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19-000348

Identifier Type: -

Identifier Source: org_study_id

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