A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
NCT ID: NCT05699200
Last Updated: 2025-06-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2023-06-01
2027-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Echocardiogram
We will collect limited ultrasound images of the heart.
Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Elastography
We will measure the elastic properties of the arteries using elastography.
Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Echocardiogram
We will collect limited ultrasound images of the heart.
Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Elastography
We will measure the elastic properties of the arteries using elastography.
Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Interventions
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Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Echocardiogram
We will collect limited ultrasound images of the heart.
Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Elastography
We will measure the elastic properties of the arteries using elastography.
Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Eligibility Criteria
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Inclusion Criteria
* For controls: no cardiac disease history
Exclusion Criteria
* Known or suspected unstable cardiac condition within 4 weeks of the study
* Active treatment with anticoagulation or dual antiplatelet therapy
* Prisoner
18 Years
FEMALE
Yes
Sponsors
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National Heart, Lung, and Blood Institute (NHLBI)
NIH
Mayo Clinic
OTHER
Responsible Party
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Marysia Tweet
Principal Investigator
Principal Investigators
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Marysia Tweet, MD, MS
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic Rochester
Rochester, Minnesota, United States
Countries
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Central Contacts
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Other Identifiers
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21-005636
Identifier Type: -
Identifier Source: org_study_id
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