Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

145 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-27

Study Completion Date

2020-02-04

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to determine whether aldosterone blood levels are predictive of cardiac remodeling at 6 months following myocardial infarction with ST elevation (STEMI), independently of conventional predictive factors (size of myocardial infarction, age, hypertension, etc.) in revascularized patients during the acute phase of MI.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Stress Echo 2020 - The International Stress Echo Study

NCT03049995

Coronary Artery Disease Heart Failure Hypertrophic Cardiomyopathy +4 more

UNKNOWN

Intracardiac Flow Remodeling in Athletes

NCT03076788

Cardiac Remodeling, Ventricular

COMPLETED

Speckle Tracking Imaging and Realtime 3 Dimensional Echocardiograhy to Study LV Function and Remodeling After Acute Myocardial Infarction (AMI)

NCT00745680

Congestive Heart Failure Mitral Regurgitation

UNKNOWN

Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging

NCT03265535

Coronary Artery Disease Myocardial Ischemia

UNKNOWN

Stress and Rest Myocardial Tomoscintigraphies Using Mono- or Double-isotope Protocol With a Semiconductor Camera

NCT02869126

Myocardial Perfusion

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

After myocardial infarction, the evolution toward cardiac failure is generally linked to a progressive worsening of cardiac dysfunction and remodeling. Cardiac remodeling is largely the consequence of myocardial injury due to myocardial infarction, although other parameters including age, arterial hypertension, etc. may also represent important predictors. Aldosterone blood levels measured within the first hours of admission for myocardial infarction is associated with increased rates of adverse outcomes. Aldosterone acts on wound healing and fibrosis processes in the myocardium as well as on systemic volemia.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Myocardial Infarction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Myocardial infarction

All patients. Patients hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days.

Intervention:

* blood sample
* MRI
* echocardiography
* urine sample
* pulmonary echography
* vascular check
* renal echography

Group Type EXPERIMENTAL

blood sample

Intervention Type BIOLOGICAL

MRI

Intervention Type PROCEDURE

echocardiography

Intervention Type PROCEDURE

urine sample

Intervention Type BIOLOGICAL

pulmonary echography

Intervention Type PROCEDURE

vascular check

Intervention Type PROCEDURE

renal echography

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood sample

Intervention Type BIOLOGICAL

MRI

Intervention Type PROCEDURE

echocardiography

Intervention Type PROCEDURE

urine sample

Intervention Type BIOLOGICAL

pulmonary echography

Intervention Type PROCEDURE

vascular check

Intervention Type PROCEDURE

renal echography

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Man or woman hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days
* Patient presenting a stable clinical state
* Patient presenting a regular sinusal cardiac rhythm
* Patient having an age ≥ 18 years

Exclusion Criteria

* Counter-indication with examination MRI
* Severe claustrophobia
* Antecedent of over-sensitiveness to gadolinium salts
* Nonischaemic Cardiopathy
* Cardiac surgery planed in the 6 months
* Women into old to procreate without effective contraception

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No