Study Results
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Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2023-06-05
2028-05-31
Brief Summary
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Description of keratoconus at baseline and during progression in 200 participants followed by the ophthalmology departments of CHU Montpellier, CHU Bordeaux and CHU Toulouse during a 2-year period. Clinical outcome, histology of the cornea and tears proteomics will be assessed in 4 groups at different points in time:
* At 6 months in participants with no intervention (risk reduction instructions: not to rub their eyes)
* At 6 months in participants with no intervention that didn't comply with the risk reduction instructions
* At 1 month in participants assigned to cross-linking surgery
* At 1 month in participants assigned to intra corneal ring surgery If both eyes are affected, both will be evaluated with their own visit agenda. Visits for no surgery participants will be set at 6 months, 12 months and 24 months in the absence of intervention (apart from the behavioral risk reduction).
Visits for surgery participants will be set at D7, 1 month, 6 months, 12 months and 24 months after the procedure: cross-linking or placement of the intra corneal ring.
Secondary objective :
Description of the association between clinical outcomes, histological progression of the cornea and tears proteomics in time, 2 years period.
Comparison of tears proteomics in 36 participants with keratoconus followed at CHU of Montpellier and healthy participants at baseline .
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Detailed Description
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The target population consist of participants with clinical keratoconus (topographic Rabinowitz criteria with slit lamp abnormalities and visual impairment), preclinical or crude keratoconus (abnormal or suspicious topography with normal slit lamp examination and normal visual acuity). They will be aged between 10 and 40 years included.
The follow-up will be taken care off by the ophthalmology departments of the Montpellier University Hospital, Bordeaux University Hospital or Toulouse University Hospital Collection of written informed consent, after a period of reflection, will be necessary for adult participants. For minors: informed consent will have to be signed by at least one of the 2 parents or legal guardians, and approval from the child will be asked after a period of reflection. All participants will have to be affiliated to the French social security system or beneficiary of such a system.
Description of the study course:
No therapeutic intervention outside of routine care will be performed. Depending on the therapeutic orientation, the follow-up is carried out as follows:
* Visits at 6 months, 12 months and 24 months in the absence of intervention (apart from the behavioral risk reduction management).
* Visits at day 7, 1 month, 6 months, 12 months and 24 months after the procedure: cross-linking or placement of the intra corneal ring.
In this study, participants will be followed for a maximum of 2.5 years. In addition to the description of keratoconus progression, we will take a tear sample using the Schirmer test to create a biobank. This tears collection will be performed in 36 participants followed at the Montpellier University Hospital, at inclusion and at short-term follow-up visit (6 months if abstention, 1 month if surgery).
Judging criteria:
* Paraclinical examination of the participants
* Ophthalmological paraclinical data
* Confocal microscopy examination
* ABCD classification of keratoconus
* Composition and evolution of tears determined by proteomic analysis
* Survey on risk factors: allergies, atopy, ocular friction, family history, ethnic origin, smoking, dry eye syndrome, low pachymetry
Prevalence of risk factors: a survey will measure the prevalence of risk factors for keratoconus:
* Presence of atopy/allergy
* Eye rubs
* Family history
* Ethnic origin
* Tobacco use
* Dry eye syndrome (survey + clinical examination)
* Low pachymetry
This self-survey will be completed at the inclusion visit and at the last follow-up visit (M24). The time to complete this questionnaire is approximately 10 minutes.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Abstention
After keratoconus diagnosis the patient won't be assigned to intervention
abstention
No surgery
Intervention (cross-linking surgery or intra corneal ring)
After keratoconus diagnosis the patient was assigned to cross linking surgery or intra corneal ring surgery
cross-linking surgery or intra corneal ring
After keratoconus diagnosis the patient was assigned to surgery
Interventions
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cross-linking surgery or intra corneal ring
After keratoconus diagnosis the patient was assigned to surgery
abstention
No surgery
Eligibility Criteria
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Inclusion Criteria
* Followed by the ophthalmology services of the CHU Montpellier, CHU Bordeaux or CHU Toulouse
* For adult Participants: collection of written informed consent, after a period of reflection period
* For minors: informed consent signed by at least one of the 2 parents or legal representatives legal representatives, and assent of the child after a period of reflection
* Affiliation to the French social security system or beneficiary of such a system
Exclusion Criteria
* History of corneal implant on both eyes
* Planned relocation before the end of the first stage of treatment (abstention, cross-linking, intra-corneal ring depending on the participant)
10 Years
40 Years
ALL
No
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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Vincent DAIEN, PR
Role: PRINCIPAL_INVESTIGATOR
CHU Monptellier
Locations
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CHU Gui de Chauliac - Service d'Ophtamologie
Montpellier, Occitanie, France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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RECHMPL20_0450 / UF8090
Identifier Type: -
Identifier Source: org_study_id
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