Machine Perfusion in High vs Low/Mid-volume Liver Transplant Centers: a Multicentre Survey

NCT ID: NCT05662969

Last Updated: 2022-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

67 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-31

Study Completion Date

2022-03-31

Brief Summary

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Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results.

Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as \>60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.

Detailed Description

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Conditions

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Organ Preservation Solution

Keywords

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machine perfusion liver transplant low/mid volume transplant center

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Low/mid-volume liver transplant centres

MACHINE PERFUSION

Intervention Type DEVICE

Different outcomes of MP use in low/mid-volume and high-volume LT centres

High-volume liver transplant centres

MACHINE PERFUSION

Intervention Type DEVICE

Different outcomes of MP use in low/mid-volume and high-volume LT centres

Interventions

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MACHINE PERFUSION

Different outcomes of MP use in low/mid-volume and high-volume LT centres

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* LT centres that use MP
* LT centres which perform LT before pandemic time (before 2019 included)
* LT centres which perform LT from cadaveric donors and living donors

Exclusion Criteria

* LT centres that not use MP
* LT centres that use MP but on clinical trials
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Roberta Angelico

OTHER

Sponsor Role lead

Responsible Party

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Roberta Angelico

Principal investigator, Professor, MD, PhD, FEBS

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Roberta Angelico

Rome, , Italy

Site Status

Countries

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Italy

Other Identifiers

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MPLTPTV1

Identifier Type: -

Identifier Source: org_study_id