Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain
NCT ID: NCT05638230
Last Updated: 2022-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2500 participants
OBSERVATIONAL
2021-08-01
2025-07-31
Brief Summary
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* Usefullness of LARS as a predictor of high HFA-PEFF diagnostic algorithm scores (≥5)
* The relative importance of LARS in variables including each component of HFA-PEFF and traditional cardiovascular risk factors.
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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HIgh HFA-PEFF points (≥5)
Left atrial reservoir strain
LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views.
In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.
Low to intermediate HFA-PEFF points (<5)
Left atrial reservoir strain
LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views.
In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.
Interventions
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Left atrial reservoir strain
LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views.
In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.
Eligibility Criteria
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Inclusion Criteria
* 20-year-old or higher age
* Participants who are available to measure left atrial reservoir strain
Exclusion Criteria
* Supraventricular arrhythmia (e.g. atrial flutter/fibrillation, atrial tachycardia)
* Participants who are given pacemaker or ICD implantation procedure
20 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Minkwan Kim, MD
Clinical assistant professor
Locations
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Minkwan Kim
Yongin, Gyeonggi-do, South Korea
Countries
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Central Contacts
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Facility Contacts
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References
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Kim M, Bae S, Park JH, Jung IH. Relative importance of left atrial reservoir strain compared with components of the HFA-PEFF score: a cross-sectional study. Front Cardiovasc Med. 2023 Oct 12;10:1213557. doi: 10.3389/fcvm.2023.1213557. eCollection 2023.
Other Identifiers
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9-2022-0101
Identifier Type: -
Identifier Source: org_study_id
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