Heart Rate and Breathing Effects on Attention and Memory

NCT ID: NCT05602220

Last Updated: 2026-01-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 91 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-01-11
• Study Completion Date: 2023-11-13

Brief Summary

In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults. Healthy adults aged 50-70 who meet all eligibility criteria will be invited to this study. Participants will be randomly assigned to one of the two conditions: 1) Daily memory and attention training followed by a paced breathing protocol designed to increase relaxation or 2) Daily memory and attention training followed by a paced breathing protocol to increase alertness. Participants will be asked to complete pre and post intervention cognitive testing online, engage in 10 weeks of daily brain training (starting Week 2) and 9 weeks of paced breathing (starting Week 3) at home. They will also be asked to come in for lab visits on Weeks 2, 7 and 12 to provide blood and urine samples to assess amyloid beta levels and to complete magnetic resonance imaging scans to assess perivascular space volume.

Conditions

Aging; Alzheimer Disease; Age-related Cognitive Decline

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Brain training and paced breathing to stimulate alertness

Group Type: EXPERIMENTAL

Paced breathing

Intervention Type: BEHAVIORAL

After completing brain training, they will then immediately do one 15-minute session of paced breathing, followed by a second 15-min session of paced breathing later in the day. During the paced breathing sessions, participants will clip a pulse monitor to their ear lobe and try to inhale and exhale in synchrony with a ball that moves up and down on the screen. They will receive heart rate biofeedback regarding whether they are achieving their relaxation/alertness goal.

Brain training

Intervention Type: BEHAVIORAL

Participants will play a few brain training games using an online interface each day. These games train attention, memory and other cognitive functions.

Brain training and paced breathing to relax

Group Type: EXPERIMENTAL

Paced breathing

Intervention Type: BEHAVIORAL

After completing brain training, they will then immediately do one 15-minute session of paced breathing, followed by a second 15-min session of paced breathing later in the day. During the paced breathing sessions, participants will clip a pulse monitor to their ear lobe and try to inhale and exhale in synchrony with a ball that moves up and down on the screen. They will receive heart rate biofeedback regarding whether they are achieving their relaxation/alertness goal.

Brain training

Intervention Type: BEHAVIORAL

Participants will play a few brain training games using an online interface each day. These games train attention, memory and other cognitive functions.

Interventions

Paced breathing

After completing brain training, they will then immediately do one 15-minute session of paced breathing, followed by a second 15-min session of paced breathing later in the day. During the paced breathing sessions, participants will clip a pulse monitor to their ear lobe and try to inhale and exhale in synchrony with a ball that moves up and down on the screen. They will receive heart rate biofeedback regarding whether they are achieving their relaxation/alertness goal.

Intervention Type: BEHAVIORAL

Brain training

Participants will play a few brain training games using an online interface each day. These games train attention, memory and other cognitive functions.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• speak English fluently
• between the age of 50-70
• healthy adult who weighs at least 110 pounds
• non-pregnant and non-menstruating (for at least the past year)
• normal or corrected-to-normal vision and hearing
• have a home computer with a physical keyboard and have access to reliable internet
• have an email account that you check regularly
• have a phone that receives text messages
• willing to provide a blood sample and a urine sample at three lab visits
• willing to devote up to 60 minutes daily to the study for 12 weeks (in addition to lab visits)

Exclusion Criteria

• have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, heart disease including coronary artery disease, angina, and arrhythmia, cognitive impairment, dyspnea)
• regularly practicing any relaxation, biofeedback, or breathing technique (e.g., meditation) for more than an hour a week
• regularly played Lumosity games in the past 6 months
• participated in heart rate biofeedback studies in the USC Emotion & Cognition Lab
• have any conditions listed below that are not safe for MRI

• Claustrophobia
• Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
• Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
• Cardiac pacemaker
• Implanted cardiac defibrillator
• Aneurysm clip or brain clip
• Carotid artery vascular clamp
• Neurostimulator
• Insulin or infusion pump
• Spinal fusion stimulator
• Cochlear, otologic, ear tubes or ear implant
• Prosthesis (eye/orbital, penile, etc.)
• Implant held in place by a magnet
• Heart valve prosthesis
• Artificial limb or joint
• Other implants in body or head
• Electrodes (on body, head or brain)
• Intravascular stents, filters
• Shunt (spinal or intraventricular)
• Vascular access port or catheters
• IUD
• Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI
• Shrapnel, buckshot, or bullets
• Tattooed eyeliner or eyebrows
• Body piercing(s) that cannot be removed for MRI
• Metal fragments (eye, head, ear, skin)
• Internal pacing wires
• Aortic clips
• Metal or wire mesh implants
• Wire sutures or surgical staples
• Harrington rods (spine)
• Bone/joint pin, screw, nail, wire, plate
• Wig or toupee that cannot be removed for MRI
• Hair implants that involve staples or metal
• Hearing aid(s) that cannot be removed for MRI
• Dentures or retainers that cannot be removed for MRI

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Southern California

OTHER

Sponsor Role: lead

University of California, Irvine

OTHER

Sponsor Role: collaborator

Responsible Party

Mara Mather

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Southern California

Los Angeles, California, United States

Countries

United States

References

Nashiro K, Yoo HJ, Cho C, Kim AJ, Nasseri P, Min J, Dahl MJ, Mercer N, Choupan J, Choi P, Lee HRJ, Choi D, Alemu K, Herrera AY, Ng NF, Thayer JF, Mather M. Heart rate and breathing effects on attention and memory (HeartBEAM): study protocol for a randomized controlled trial in older adults. Trials. 2024 Mar 15;25(1):190. doi: 10.1186/s13063-024-07943-y.

Reference Type: DERIVED

PMID: 38491546 (View on PubMed)

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

UP-21-00357

Identifier Type: -

Identifier Source: org_study_id