Reducing Blood Pressure in Mid-life Adult Binge Drinkers
NCT ID: NCT05522075
Last Updated: 2025-11-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
55 participants
INTERVENTIONAL
2022-11-21
2026-04-30
Brief Summary
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Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.
Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Exercise Group
Binge drinkers who have been assigned to exercise group will receive baseline assessment, 8-week exercise training plus alcohol abstinence intervention, and post-intervention assessment.
Exercise Training
Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.
Alcohol Abstinence Intervention
Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
Non-exercise Group
Binge drinkers who have been assigned to non-exercise group will receive baseline assessment, 8-week alcohol abstinence intervention, and post-intervention assessment.
Alcohol Abstinence Intervention
Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
Alcohol abstainer/moderate drinker group
Alcohol abstainer/moderate drinker will complete baseline assessment only and will not receive any intervention.
No interventions assigned to this group
Interventions
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Exercise Training
Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.
Alcohol Abstinence Intervention
Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
Eligibility Criteria
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Inclusion Criteria
* Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
* Subjects who can speak and understand English.
Exclusion Criteria
* current or history of smoking and illicit drug use
* blood pressure ≥160/100 mm Hg
* other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol\>230 mg/dl and/or LDL cholesterol\>160 mg/dl)
* active infection (in the past 2 months)
* a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)
* unstable body weight (\>5% change during the past 6 months)
* regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)
* current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)
50 Years
64 Years
ALL
Yes
Sponsors
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The University of Texas at Arlington
OTHER
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Responsible Party
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Principal Investigators
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Chueh-Lung Hwang, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Texas at Arlington
Locations
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University of Texas at Arlington
Arlington, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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Chueh-Lung Hwang, PhD, PT
Role: primary
Other Identifiers
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2200-0189
Identifier Type: -
Identifier Source: org_study_id