Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2019-11-13
2023-03-31
Brief Summary
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Detailed Description
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1\. To test the hypothesis that two weeks of sedentary behavior will progressively impair vascular endothelial function.
2: To test the hypothesis that increasing sedentary behavior will decrease total sleep duration and sleep efficiency.
3: To test the hypothesis that two-weeks of sedentary behavior will progressively increase 24-h blood pressure and reduce nocturnal blood pressure dipping.
OUTLINE:
After a baseline period, participants will become more inactive and also come in for 4-h uninterrupted sitting visits. Cardiovascular, activity, and sleep measures will be taken throughout.
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Sedentary to Active
Participants will visit the research laboratory for baseline measurements at visit 1 after wearing a pedometer for one week and maintaining their typical level of physical activity. After the baseline visit, participants will reduce their step count by more than half for two weeks. Participants will visit the laboratory once every week during the 2 week interventional period for a total of 3 visits.
Reduced Activity
Participants reduce their activity level to \<5,000 steps/day and \<50 % of baseline steps.
Interventions
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Reduced Activity
Participants reduce their activity level to \<5,000 steps/day and \<50 % of baseline steps.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Lean and overweight (BMI 18.5-40 kg/m2)
* No acute, chronic, or debilitating medical conditions
* No prescription/non-prescription medications or drugs of abuse
* Limited weight training or intense exercise (swimming, CrossFit)
* Non-smoker
* Average level of daily physical activity (8,000-12,499 steps/day)
* Persons who fit all the above criteria and are suitable based on a medical history and health habits questionnaire, sleep profiling questionnaire, and electrocardiogram and clinical biochemical screening tests of blood and urine may be eligible to participate.
Exclusion Criteria
* Persons with any symptoms of acute or active illness (e.g. fever, leukocytosis) will be excluded.
* Persons with a history of severe psychiatric illness or psychiatric disorders will be excluded.
* Persons with a history of regular night/or rotating shift work, or who have traveled more than three time zones during the one month prior to the study will be excluded.
* Pregnant persons, decisionally impaired adults, and prisoners will be excluded.
20 Years
80 Years
ALL
Yes
Sponsors
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Oregon Health and Science University
OTHER
Responsible Party
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Saurabh Thosar
Principal Investigator
Principal Investigators
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Saurabh Thosar, Dr.
Role: PRINCIPAL_INVESTIGATOR
Oregon Institute of Occupational Health Sciences
Locations
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Oregon Institute of Occupational Health Sciences
Portland, Oregon, United States
Countries
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Facility Contacts
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Other Identifiers
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STUDY00020458
Identifier Type: -
Identifier Source: org_study_id
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