Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury

NCT ID: NCT05585866

Last Updated: 2024-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-22

Study Completion Date

2025-12-31

Brief Summary

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The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury.

The main questions it aims to answer are:

* is there a difference in acute kidney injury incidence in the two anesthetic modalities?
* is there a difference in plasma creatinine between the two anesthetic modalities?
* are there any patient characteristics or intraoperative factors that effect the incidence of acute kidney injury in either anesthetic modality?

The study will analyze data from the CAN clinical trial database. (Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia, NCT01975064)

Detailed Description

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Conditions

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Acute Kidney Injury Cancer Colorectal

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Sevoflurane

The group of patients which received sevoflurane as randomized anesthetic modality.

Anesthesia Agent

Intervention Type DRUG

The two anesthetic modalities included intravenous propofol anesthesia and sevoflurane gas anesthesia administered according to standard clinical praxis.

Propofol

The group of patients which received propofol as randomized anesthetic modality.

Anesthesia Agent

Intervention Type DRUG

The two anesthetic modalities included intravenous propofol anesthesia and sevoflurane gas anesthesia administered according to standard clinical praxis.

Interventions

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Anesthesia Agent

The two anesthetic modalities included intravenous propofol anesthesia and sevoflurane gas anesthesia administered according to standard clinical praxis.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* colorectal surgery and participant in the CAN trial

Exclusion Criteria

* missing blood samples
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Uppsala University

Uppsala, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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PROSACC2021

Identifier Type: -

Identifier Source: org_study_id

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